Switching trypanosome coats: what's in the wardrobe? - PubMed (original) (raw)

Review

. 2006 Nov;22(11):614-20.

doi: 10.1016/j.tig.2006.08.003. Epub 2006 Aug 14.

Affiliations

• PMID: 16908087
• DOI: 10.1016/j.tig.2006.08.003

Review

Switching trypanosome coats: what's in the wardrobe?

Jesse E Taylor et al. Trends Genet. 2006 Nov.

Abstract

The African trypanosome Trypanosoma brucei is best known for its extraordinarily sophisticated antigenic variation of a protective variant surface glycoprotein (VSG) coat. T. brucei has >1000 VSG genes and pseudogenes, of which one is transcribed at a time from one of multiple telomeric VSG expression sites. Switching the active VSG gene can involve DNA rearrangements replacing the old VSG with a new one, or alternatively transcriptional control. The astonishing revelation from the T. brucei genome sequence is that <7% of the sequenced VSGs seem to have fully functional coding regions. This preponderance of pseudogenes in the VSG gene repertoire will necessitate a rethink of how antigenic variation in African trypanosomes operates.

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