Genome-wide patterns of histone modifications in yeast - PubMed (original) (raw)

Review

doi: 10.1038/nrm1986. Epub 2006 Aug 16.

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Review

Genome-wide patterns of histone modifications in yeast

Catherine B Millar et al. Nat Rev Mol Cell Biol. 2006 Sep.

Abstract

Post-translational histone modifications and histone variants generate complexity in chromatin to enable the many functions of the chromosome. Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome. These experiments describe how combinations of modified and unmodified states relate to each other and particularly to chromosomal landmarks that include heterochromatin, subtelomeric chromatin, centromeres, origins of replication, promoters and coding regions. Such patterns might be important for the regulation of heterochromatin-mediated silencing, chromosome segregation, DNA replication and gene expression.

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