TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis - PubMed (original) (raw)
. 2006 Sep;12(9):1088-92.
doi: 10.1038/nm1449. Epub 2006 Jul 20.
Affiliations
- PMID: 16921377
- DOI: 10.1038/nm1449
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
Carolyn G King et al. Nat Med. 2006 Sep.
Abstract
TRAF6 has a key role in the regulation of innate immune responses by mediating signals from both TNF receptor and interleukin-1 receptor/Toll-like receptor superfamilies. Here we show that T cell-specific deletion of TRAF6 unexpectedly results in multiorgan inflammatory disease. TRAF6-deficient T cells exhibit hyperactivation of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway compared with wild-type T cells and, as a result, become resistant to suppression by CD4+ CD25+ regulatory T cells. These data identify a previously unrecognized role for TRAF6 in the maintenance of peripheral tolerance, and suggest the presence of a T cell-intrinsic control mechanism to render responder T cells susceptible to tolerizing signals.
Comment in
- Supressing the supressors.
Ohashi PS, Yeh WC. Ohashi PS, et al. Nat Med. 2006 Sep;12(9):1000-2. doi: 10.1038/nm0906-1000. Nat Med. 2006. PMID: 16960572 No abstract available.
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