Notch signalling: a simple pathway becomes complex - PubMed (original) (raw)
Review
doi: 10.1038/nrm2009.
Affiliations
- PMID: 16921404
- DOI: 10.1038/nrm2009
Review
Notch signalling: a simple pathway becomes complex
Sarah J Bray. Nat Rev Mol Cell Biol. 2006 Sep.
Abstract
A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Similar articles
- Notch signalling is required for both dauer maintenance and recovery in C. elegans.
Ouellet J, Li S, Roy R. Ouellet J, et al. Development. 2008 Aug;135(15):2583-92. doi: 10.1242/dev.012435. Epub 2008 Jul 3. Development. 2008. PMID: 18599512 - Notch signalling: multifaceted role in development and disease.
Sachan N, Sharma V, Mutsuddi M, Mukherjee A. Sachan N, et al. FEBS J. 2024 Jul;291(14):3030-3059. doi: 10.1111/febs.16815. Epub 2023 May 30. FEBS J. 2024. PMID: 37166442 Review. - Cell and molecular biology of Notch.
Fiúza UM, Arias AM. Fiúza UM, et al. J Endocrinol. 2007 Sep;194(3):459-74. doi: 10.1677/JOE-07-0242. J Endocrinol. 2007. PMID: 17761886 Review. - Complex crosstalk of Notch and Hedgehog signalling during the development of the central nervous system.
Jacobs CT, Huang P. Jacobs CT, et al. Cell Mol Life Sci. 2021 Jan;78(2):635-644. doi: 10.1007/s00018-020-03627-3. Epub 2020 Sep 3. Cell Mol Life Sci. 2021. PMID: 32880661 Free PMC article. Review. - Canonical Notch signalling is inactive in urothelial carcinoma.
Greife A, Jankowiak S, Steinbring J, Nikpour P, Niegisch G, Hoffmann MJ, Schulz WA. Greife A, et al. BMC Cancer. 2014 Aug 29;14:628. doi: 10.1186/1471-2407-14-628. BMC Cancer. 2014. PMID: 25167871 Free PMC article.
Cited by
- Fruit flies in biomedical research.
Wangler MF, Yamamoto S, Bellen HJ. Wangler MF, et al. Genetics. 2015 Mar;199(3):639-53. doi: 10.1534/genetics.114.171785. Epub 2015 Jan 26. Genetics. 2015. PMID: 25624315 Free PMC article. - Notch signaling at a glance.
Hori K, Sen A, Artavanis-Tsakonas S. Hori K, et al. J Cell Sci. 2013 May 15;126(Pt 10):2135-40. doi: 10.1242/jcs.127308. Epub 2013 May 31. J Cell Sci. 2013. PMID: 23729744 Free PMC article. Review. - A gp130-Src-YAP module links inflammation to epithelial regeneration.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. Taniguchi K, et al. Nature. 2015 Mar 5;519(7541):57-62. doi: 10.1038/nature14228. Epub 2015 Feb 25. Nature. 2015. PMID: 25731159 Free PMC article. - Reversible regulation of stem cell niche size associated with dietary control of Notch signalling.
Bonfini A, Wilkin MB, Baron M. Bonfini A, et al. BMC Dev Biol. 2015 Jan 31;15:8. doi: 10.1186/s12861-015-0059-8. BMC Dev Biol. 2015. PMID: 25637382 Free PMC article. - Separable Roles for Neur and Ubiquitin in Delta Signalling in the Drosophila CNS Lineages.
Kalodimou K, Stapountzi M, Vüllings N, Seib E, Klein T, Delidakis C. Kalodimou K, et al. Cells. 2023 Dec 14;12(24):2833. doi: 10.3390/cells12242833. Cells. 2023. PMID: 38132160 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases