A meta-analysis of the effect of soy protein supplementation on serum lipids - PubMed (original) (raw)
Meta-Analysis
. 2006 Sep 1;98(5):633-40.
doi: 10.1016/j.amjcard.2006.03.042. Epub 2006 Jul 12.
Affiliations
- PMID: 16923451
- DOI: 10.1016/j.amjcard.2006.03.042
Meta-Analysis
A meta-analysis of the effect of soy protein supplementation on serum lipids
Kristi Reynolds et al. Am J Cardiol. 2006.
Abstract
Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease. Some, but not all, studies have shown that soy protein intake decreases total and low-density lipoprotein cholesterol and triglycerides and increases high-density lipoprotein cholesterol. The objective of this meta-analysis was to examine the effect of soy protein supplementation on serum lipid levels in adults. English language articles were retrieved by searching MEDLINE (1966 to February 2005) and the bibliographies of the retrieved articles. A total of 41 randomized controlled trials in which isolated soy protein supplementation was the only intervention and the net changes in serum lipids during intervention were reported. Information on study design, sample size, participant characteristics, intervention, follow-up duration, and treatment outcomes was independently abstracted using a standardized protocol. Using a random-effects model, data from each study were pooled and weighted by the inverse of their variance. Soy protein supplementation was associated with a significant reduction in mean serum total cholesterol (-5.26 mg/dl, 95% confidence interval [CI] -7.14 to -3.38), low-density lipoprotein cholesterol (-4.25 mg/dl, 95% CI -6.00 to -2.50), and triglycerides (-6.26 mg/dl, 95% CI -9.14 to -3.38) and a significant increase in high-density lipoprotein cholesterol (0.77 mg/dl, 95% CI 0.20 to 1.34). Meta-regression analyses showed a dose-response relation between soy protein and isoflavone supplementation and net changes in serum lipids. These results indicate that soy protein supplementation reduces serum lipids among adults with or without hypercholesterolemia. In conclusion, replacing foods high in saturated fat, trans-saturated fat, and cholesterol with soy protein may have a beneficial effect on coronary risk factors.
Similar articles
- Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects.
Hermansen K, Hansen B, Jacobsen R, Clausen P, Dalgaard M, Dinesen B, Holst JJ, Pedersen E, Astrup A. Hermansen K, et al. Eur J Clin Nutr. 2005 Jul;59(7):843-50. doi: 10.1038/sj.ejcn.1602151. Eur J Clin Nutr. 2005. PMID: 15900307 Clinical Trial. - Effectiveness of a soy-based compared with a traditional low-calorie diet on weight loss and lipid levels in overweight adults.
Liao FH, Shieh MJ, Yang SC, Lin SH, Chien YW. Liao FH, et al. Nutrition. 2007 Jul-Aug;23(7-8):551-6. doi: 10.1016/j.nut.2007.05.003. Epub 2007 Jun 15. Nutrition. 2007. PMID: 17574819 Clinical Trial. - Variable effects of soy protein on plasma lipids in hyperlipidemic and normolipidemic hemodialysis patients.
Chen ST, Ferng SH, Yang CS, Peng SJ, Lee HR, Chen JR. Chen ST, et al. Am J Kidney Dis. 2005 Dec;46(6):1099-106. doi: 10.1053/j.ajkd.2005.08.031. Am J Kidney Dis. 2005. PMID: 16310576 Clinical Trial. - Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials.
Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS Jr, Brehm BJ, Bucher HC. Nordmann AJ, et al. Arch Intern Med. 2006 Feb 13;166(3):285-93. doi: 10.1001/archinte.166.3.285. Arch Intern Med. 2006. PMID: 16476868 Review. - Almonds have a neutral effect on serum lipid profiles: a meta-analysis of randomized trials.
Phung OJ, Makanji SS, White CM, Coleman CI. Phung OJ, et al. J Am Diet Assoc. 2009 May;109(5):865-73. doi: 10.1016/j.jada.2009.02.014. J Am Diet Assoc. 2009. PMID: 19394473 Review.
Cited by
- Legume Consumption and Cardiometabolic Health.
Becerra-Tomás N, Papandreou C, Salas-Salvadó J. Becerra-Tomás N, et al. Adv Nutr. 2019 Nov 1;10(Suppl_4):S437-S450. doi: 10.1093/advances/nmz003. Adv Nutr. 2019. PMID: 31728491 Free PMC article. Review. - Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis).
Register TC. Register TC. Am J Primatol. 2009 Sep;71(9):766-75. doi: 10.1002/ajp.20722. Am J Primatol. 2009. PMID: 19530126 Free PMC article. Review. - Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects.
Legette LL, Lee WH, Martin BR, Story JA, Arabshahi A, Barnes S, Weaver CM. Legette LL, et al. Menopause. 2011 Aug;18(8):923-31. doi: 10.1097/gme.0b013e3182116e81. Menopause. 2011. PMID: 21659907 Free PMC article. - Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial.
Wofford MR, Rebholz CM, Reynolds K, Chen J, Chen CS, Myers L, Xu J, Jones DW, Whelton PK, He J. Wofford MR, et al. Eur J Clin Nutr. 2012 Apr;66(4):419-25. doi: 10.1038/ejcn.2011.168. Epub 2011 Sep 28. Eur J Clin Nutr. 2012. PMID: 21952693 Free PMC article. Clinical Trial. - Whole Soy Flour Incorporated into a Muffin and Consumed at 2 Doses of Soy Protein Does Not Lower LDL Cholesterol in a Randomized, Double-Blind Controlled Trial of Hypercholesterolemic Adults.
Padhi EM, Blewett HJ, Duncan AM, Guzman RP, Hawke A, Seetharaman K, Tsao R, Wolever TM, Ramdath DD. Padhi EM, et al. J Nutr. 2015 Dec;145(12):2665-74. doi: 10.3945/jn.115.219873. Epub 2015 Oct 7. J Nutr. 2015. PMID: 26446482 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical