A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites - PubMed (original) (raw)
. 1990 May;136(5):1053-68.
Affiliations
- PMID: 1693467
- PMCID: PMC1877421
A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites
L J Picker et al. Am J Pathol. 1990 May.
Abstract
It has been proposed that the skin is a functionally unique compartment of the immune system, although little direct evidence supporting this hypothesis has been presented. Here we show that lymphocyte populations at cutaneous sites can be differentiated from otherwise similar populations at noncutaneous sites by their preferential expression of an epitope defined by the MAb HECA-452. This MAb recognizes a predominantly 200-kd cell-surface glycoprotein present on about 16% of peripheral blood T cells, including both CD4+ and CD8+ T cells (17% and 11% HECA-452+, respectively), as well as TCR-delta-bearing T cells (32%+). Most thymocytes (99%) lacked HECA-452 antigen expression, and essentially all the HECA-452+ peripheral blood T cells were found in the adhesion molecule high, CD45R low putative memory cell subset, findings suggesting that HECA-452 expression develops peripherally as a consequence of antigenic stimulation. However, the HECA-452 antigen is not a conventional activation antigen because it was not upregulated with mitogen stimulation of peripheral blood T cells. Most significantly, among 54 diverse specimens of normal/reactive lymphoid tissues and sites of chronic inflammation, there was a clear association of lymphocyte HECA-452 expression and cutaneous location. In extracutaneous sites (n = 38) only about 5% of lymphocytes within the T-cell areas of these tissues expressed this antigen, whereas in inflammatory skin lesions (n = 16), 85% were HECA-452+. The association of HECA-452 expression and cutaneous location was also seen in a series of T-cell lymphomas. The malignant cells of 16 of 18 cases of epidermotropic (patch/plaque) stage mycosis fungoides were HECA-452+, as well as 2 of 7 nonmycosis fungoides peripheral T-cell lymphomas in skin. In contrast, this antigen was not expressed in thymic (lymphoblastic) lymphomas (n = 14), nonepidermotropic (tumor) stage mycosis fungoides (n = 5), and noncutaneous peripheral T-cell lymphomas (n = 15). Among lymphocytes, the preferential expression of the HECA-452 determinant by cutaneous T cells supports the hypothesis that the skin constitutes a immunologically unique lymphoid tissue and suggests that this molecule may play a role in either lymphocyte homing to skin or in lymphocyte interactions with the epidermis.
Similar articles
- Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates.
Magro CM, Dyrsen ME. Magro CM, et al. J Cutan Pathol. 2008 Nov;35(11):1040-9. doi: 10.1111/j.1600-0560.2007.00971.x. Epub 2008 Aug 4. J Cutan Pathol. 2008. PMID: 18681860 - Differential expression of homing-associated adhesion molecules by T cell subsets in man.
Picker LJ, Terstappen LW, Rott LS, Streeter PR, Stein H, Butcher EC. Picker LJ, et al. J Immunol. 1990 Nov 15;145(10):3247-55. J Immunol. 1990. PMID: 1700003 - Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C. Jawed SI, et al. J Am Acad Dermatol. 2014 Feb;70(2):205.e1-16; quiz 221-2. doi: 10.1016/j.jaad.2013.07.049. J Am Acad Dermatol. 2014. PMID: 24438969 Review. - Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia.
Knowles DM. Knowles DM. Am J Pathol. 1989 Apr;134(4):761-85. Am J Pathol. 1989. PMID: 2495724 Free PMC article. Review.
Cited by
- Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions.
Line J, Saville E, Meng X, Naisbitt D. Line J, et al. Front Toxicol. 2023 Sep 19;5:1268107. doi: 10.3389/ftox.2023.1268107. eCollection 2023. Front Toxicol. 2023. PMID: 37795379 Free PMC article. Review. - Cellular activation pathways and interaction networks in vascularized composite allotransplantation.
Knoedler L, Knoedler S, Panayi AC, Lee CAA, Sadigh S, Huelsboemer L, Stoegner VA, Schroeter A, Kern B, Mookerjee V, Lian CG, Tullius SG, Murphy GF, Pomahac B, Kauke-Navarro M. Knoedler L, et al. Front Immunol. 2023 May 17;14:1179355. doi: 10.3389/fimmu.2023.1179355. eCollection 2023. Front Immunol. 2023. PMID: 37266446 Free PMC article. Review. - Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients.
Sans-de San Nicolàs L, Figueras-Nart I, García-Jiménez I, Bonfill-Ortí M, Guilabert A, Curto-Barredo L, Bertolín-Colilla M, Ferran M, Serra-Baldrich E, Pujol RM, Santamaria-Babí LF. Sans-de San Nicolàs L, et al. Front Immunol. 2023 Mar 13;14:1124018. doi: 10.3389/fimmu.2023.1124018. eCollection 2023. Front Immunol. 2023. PMID: 36993985 Free PMC article. - Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia.
Bozorgmehr N, Hnatiuk M, Peters AC, Elahi S. Bozorgmehr N, et al. Exp Hematol Oncol. 2023 Jan 27;12(1):13. doi: 10.1186/s40164-023-00375-5. Exp Hematol Oncol. 2023. PMID: 36707896 Free PMC article. - Flow cytometry for the assessment of blood tumour burden in cutaneous T-cell lymphoma: towards a standardized approach.
Vermeer MH, Moins-Teisserenc H, Bagot M, Quaglino P, Whittaker S. Vermeer MH, et al. Br J Dermatol. 2022 Jul;187(1):21-28. doi: 10.1111/bjd.21053. Epub 2022 May 3. Br J Dermatol. 2022. PMID: 35157307 Free PMC article. Review.
References
- Eur J Immunol. 1989 Jan;19(1):63-8 - PubMed
- Nature. 1970 Aug 15;227(5259):680-5 - PubMed
- J Cell Biol. 1988 Nov;107(5):1853-62 - PubMed
- J Immunol. 1986 Jan;136(1):76-82 - PubMed
- Am J Pathol. 1987 Jul;128(1):181-201 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials