Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury - PubMed (original) (raw)
Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury
A S Gorgey et al. Spinal Cord. 2007 Apr.
Abstract
Study design: Cross-sectional and longitudinal design.
Objectives: (1) To quantify skeletal muscle cross-sectional area (CSA) after correcting for intramuscular fat (IMF) in thigh muscle groups 6 weeks after incomplete spinal cord injury (SCI), (2) to monitor the changes in muscle CSA and IMF after 3 months from the initial measurement.
Setting: Academic institution Athens, GA, USA.
Methods: Six incomplete SCI patients (28+/-4 years, 178+/-5 cm and 78+/-6 kg, mean+/-SE, C7 to L3, American Spinal Injury Association B or C) were tested at 5+/-1 weeks and 3 months after the initial measurement. T1-weighted magnetic resonance images were taken of both thighs. Six able-bodied (AB) controls were matched in age, sex, height and weight (29+/-4 years, four male and two female subjects, 179+/-5 cm and 77+/-6 kg).
Results: At 6 weeks post-injury, muscle CSA was 82+/-4 cm(2) in incomplete SCI and 123+/-21 cm(2) in AB controls (P=0.04). IMF CSA was 5.2+/-1.3 and 2.3+/-0.6 cm(2) in incomplete SCI and AB controls, respectively (P=0.03). Relative IMF was three-fold higher (P=0.03) in the SCI group versus AB controls (5.8+/-1.4 versus 2.0+/-0.6%). After 3 months, IMF increased 26% in the SCI group compared to the initial measurement (P=0.02).
Conclusions: Skeletal muscle atrophy is associated with greater IMF accumulation in SCI group 6 weeks post-injury compared to AB controls. Moreover, IMF continues to increase over time in incomplete SCI.
Similar articles
- Spasticity may defend skeletal muscle size and composition after incomplete spinal cord injury.
Gorgey AS, Dudley GA. Gorgey AS, et al. Spinal Cord. 2008 Feb;46(2):96-102. doi: 10.1038/sj.sc.3102087. Epub 2007 Jul 17. Spinal Cord. 2008. PMID: 17637764 - Lower-extremity muscle cross-sectional area after incomplete spinal cord injury.
Shah PK, Stevens JE, Gregory CM, Pathare NC, Jayaraman A, Bickel SC, Bowden M, Behrman AL, Walter GA, Dudley GA, Vandenborne K. Shah PK, et al. Arch Phys Med Rehabil. 2006 Jun;87(6):772-8. doi: 10.1016/j.apmr.2006.02.028. Arch Phys Med Rehabil. 2006. PMID: 16731211 - Disuse muscle atrophy exacerbates motor neuronal degeneration caudal to the site of spinal cord injury.
Ohnishi Y, Iwatsuki K, Shinzawa K, Nakai Y, Ishihara M, Yoshimine T. Ohnishi Y, et al. Neuroreport. 2012 Feb 15;23(3):157-61. doi: 10.1097/WNR.0b013e32834f4048. Neuroreport. 2012. PMID: 22182976 - Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma.
Mori K, Chano T, Matsumoto K, Ishizawa M, Matsusue Y, Okabe H. Mori K, et al. BMC Musculoskelet Disord. 2004 Jun 18;5:20. doi: 10.1186/1471-2474-5-20. BMC Musculoskelet Disord. 2004. PMID: 15202946 Free PMC article. Review. - Disruption in bone marrow fat may attenuate testosterone action on muscle size after spinal cord injury: a case report.
Gorgey AS, Moore PD, Wade RC, Gill RS, Lavis T, Adler RA. Gorgey AS, et al. Eur J Phys Rehabil Med. 2017 Aug;53(4):625-629. doi: 10.23736/S1973-9087.17.04452-5. Epub 2017 Mar 13. Eur J Phys Rehabil Med. 2017. PMID: 28290190 Review.
Cited by
- The effect of home-based neuromuscular electrical stimulation-resistance training and protein supplementation on lean mass in persons with spinal cord injury: A pilot study.
Hoekstra S, King JA, Fenton J, Kirk N, Willis SA, Phillips SM, Webborn N, Tolfrey K, Bosch JVD, Goosey-Tolfrey VL. Hoekstra S, et al. Physiol Rep. 2024 Oct;12(19):e70073. doi: 10.14814/phy2.70073. Physiol Rep. 2024. PMID: 39358836 Free PMC article. Clinical Trial. - Short-Term and Long-Term Risk of Diabetes Mellitus among Patients with Spinal Cord Injury: A Nationwide Retrospective Cohort Study.
Kim S, Han KD, Kim B, Min JH, Chang WH, Cho IY, Shin DW. Kim S, et al. Healthcare (Basel). 2024 Sep 15;12(18):1859. doi: 10.3390/healthcare12181859. Healthcare (Basel). 2024. PMID: 39337199 Free PMC article. - Age-related changes in ultrasound-assessed muscle composition and postural stability.
Mongold SJ, Georgiev C, Naeije G, Vander Ghinst M, Stock MS, Bourguignon M. Mongold SJ, et al. Sci Rep. 2024 Aug 12;14(1):18688. doi: 10.1038/s41598-024-69374-8. Sci Rep. 2024. PMID: 39134635 Free PMC article. - Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences.
Norris AM, Fierman KE, Campbell J, Pitale R, Shahraj M, Kopinke D. Norris AM, et al. Skelet Muscle. 2024 May 29;14(1):12. doi: 10.1186/s13395-024-00344-4. Skelet Muscle. 2024. PMID: 38812056 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous