Neurotransmitters and neuromodulators in the basal ganglia - PubMed (original) (raw)

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Neurotransmitters and neuromodulators in the basal ganglia

A M Graybiel. Trends Neurosci. 1990 Jul.

Abstract

The basal ganglia have become a focus for work on neurotransmitter interactions in the brain. These structures contain a remarkable diversity of neuroactive substances, organized into functional subsystems that have unique developmental histories and vulnerabilities in neurodegenerative diseases. A new view of the basal ganglia is emerging on the basis of this neurochemical heterogeneity, suggesting that dynamic regulation of transmitter expression may be a key to extrapyramidal function.

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