Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size - PubMed (original) (raw)
. 2006 Dec;23(12):2268-70.
doi: 10.1093/molbev/msl105. Epub 2006 Sep 6.
Affiliations
- PMID: 16956974
- DOI: 10.1093/molbev/msl105
Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size
Lev A Zhivotovsky et al. Mol Biol Evol. 2006 Dec.
Abstract
Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller.
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