Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples - PubMed (original) (raw)
Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples
C N Andreassen et al. Int J Radiat Biol. 2006 Aug.
Abstract
Purpose: In two previously published studies, associations with risk of radiation-induced subcutaneous fibrosis were found for single nucleotide polymorphisms (SNP) in TGFB1 (transforming growth factor beta 1 gene), XRCC1 (X-ray repair cross-complementing 1 gene), XRCC3 (X-ray repair cross-complementing 3 gene), SOD2 (manganese superoxide dismutase gene) and ATM (gene of ataxia telangiectasia mutated). The present study was conducted to seek a confirmation of these findings.
Materials and methods: Like the 41 patients previously investigated, the 120 subjects included in the present study were accrued from a historical cohort of 319 post-mastectomy radiotherapy patients. All patients received hypo-fractionated radiotherapy. The TGFB1 position--509, codons 10 and 25, XRCC1 codons 194, 280 and 399, XRCC3 codon 241, SOD2 codon 16, ATM codon 1853 and APEX (apurinic/apyrimidinic exonuclease gene) codon 148 polymorphisms were assessed based on archival histological material. Differences in fibrosis risk were quantified from dose-response assessments.
Results: For none of the investigated polymorphisms, significant associations with risk of subcutaneous fibrosis were observed. A detailed analysis did not reveal any obvious explanation for the discrepancy between the previous and the present study.
Conclusion: The previously observed associations with risk of radiation-induced subcutaneous fibrosis could not be replicated in the present study. Further studies are needed to elucidate the influence of genetic variation upon normal tissue radiosensitivity.
Similar articles
- Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.
Zschenker O, Raabe A, Boeckelmann IK, Borstelmann S, Szymczak S, Wellek S, Rades D, Hoeller U, Ziegler A, Dikomey E, Borgmann K. Zschenker O, et al. Radiother Oncol. 2010 Oct;97(1):26-32. doi: 10.1016/j.radonc.2010.01.016. Epub 2010 Feb 17. Radiother Oncol. 2010. PMID: 20170971 - Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients.
Terrazzino S, La Mattina P, Gambaro G, Masini L, Franco P, Canonico PL, Genazzani AA, Krengli M. Terrazzino S, et al. Int J Radiat Oncol Biol Phys. 2012 Jun 1;83(2):504-11. doi: 10.1016/j.ijrobp.2011.06.2012. Epub 2011 Nov 11. Int J Radiat Oncol Biol Phys. 2012. PMID: 22079734 - Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes.
De Ruyck K, Van Eijkeren M, Claes K, Morthier R, De Paepe A, Vral A, De Ridder L, Thierens H. De Ruyck K, et al. Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):1140-9. doi: 10.1016/j.ijrobp.2004.12.027. Int J Radiat Oncol Biol Phys. 2005. PMID: 15990020 - XRCC1 polymorphism and lung cancer risk.
Schneider J, Classen V, Helmig S. Schneider J, et al. Expert Rev Mol Diagn. 2008 Nov;8(6):761-80. doi: 10.1586/14737159.8.6.761. Expert Rev Mol Diagn. 2008. PMID: 18999926 Review. - Genetic markers for prediction of normal tissue toxicity after radiotherapy.
Alsner J, Andreassen CN, Overgaard J. Alsner J, et al. Semin Radiat Oncol. 2008 Apr;18(2):126-35. doi: 10.1016/j.semradonc.2007.10.004. Semin Radiat Oncol. 2008. PMID: 18314067 Review.
Cited by
- Association between single nucleotide polymorphisms in DNA repair genes and the efficacy of radiotherapy in nasopharyngeal carcinoma patients.
Benzeid R, Gihbid A, Tawfik N, Benchakroun N, Bendahhou K, Benider A, Guensi A, Benna NE, Maltouf AF, Mzibri ME, Attaleb M, Khyatti M, Chaoui I. Benzeid R, et al. Contemp Oncol (Pozn). 2023;27(1):28-34. doi: 10.5114/wo.2023.127307. Epub 2023 Apr 27. Contemp Oncol (Pozn). 2023. PMID: 37266339 Free PMC article. - Association of polymorphisms in TGFB1, XRCC1, XRCC3 genes and CD8 T-lymphocyte apoptosis with adverse effect of radiotherapy for prostate cancer.
Mališić E, Petrović N, Brengues M, Azria D, Matić IZ, Srbljak Ćuk I, Kopčalić K, Stanojković T, Nikitović M. Mališić E, et al. Sci Rep. 2022 Dec 9;12(1):21306. doi: 10.1038/s41598-022-25328-6. Sci Rep. 2022. PMID: 36494413 Free PMC article. - Genetic Variants of DNA Repair Genes as Predictors of Radiation-Induced Subcutaneous Fibrosis in Oropharyngeal Carcinoma.
Gupta A, Mathew D, Bhat SA, Ghoshal S, Pal A. Gupta A, et al. Front Oncol. 2021 May 17;11:652049. doi: 10.3389/fonc.2021.652049. eCollection 2021. Front Oncol. 2021. PMID: 34079756 Free PMC article. - Biomarkers of Brain Damage Induced by Radiotherapy.
Sultana N, Sun C, Katsube T, Wang B. Sultana N, et al. Dose Response. 2020 Jul 9;18(3):1559325820938279. doi: 10.1177/1559325820938279. eCollection 2020 Jul-Sep. Dose Response. 2020. PMID: 32694960 Free PMC article. Review. - Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.
Drobin K, Marczyk M, Halle M, Danielsson D, Papiez A, Sangsuwan T, Bendes A, Hong MG, Qundos U, Harms-Ringdahl M, Wersäll P, Polanska J, Schwenk JM, Haghdoost S. Drobin K, et al. Cancers (Basel). 2020 Mar 22;12(3):753. doi: 10.3390/cancers12030753. Cancers (Basel). 2020. PMID: 32235817 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous