Serotonin transporter genotype and acute subjective response to amphetamine - PubMed (original) (raw)

Randomized Controlled Trial

. 2006 Sep-Oct;15(5):327-35.

doi: 10.1080/10550490600859868.

Affiliations

• PMID: 16966188
• DOI: 10.1080/10550490600859868

Randomized Controlled Trial

Serotonin transporter genotype and acute subjective response to amphetamine

David C Lott et al. Am J Addict. 2006 Sep-Oct.

Abstract

The authors have previously shown an effect of dopamine transporter genotype on acute subjective responses to d-amphetamine, which may affect risk of addiction. They now report the results of an evaluation of the role of the serotonin transporter gene (HTT) using a double-blind, placebo-controlled, crossover design in which subjects (N = 101) completed self-report measures of subjective effect. The separate and combined analyses of the gene-linked polymorphic region (5-HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d-amphetamine with a small effect.

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