Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo - PubMed (original) (raw)

. 1990 Aug 16;346(6285):629-33.

doi: 10.1038/346629a0.

Affiliations

• PMID: 1696684
• DOI: 10.1038/346629a0

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

H Pircher et al. Nature. 1990.

Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

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