Ancestry-environment interactions and asthma risk among Puerto Ricans - PubMed (original) (raw)

Multicenter Study

. 2006 Nov 15;174(10):1088-93.

doi: 10.1164/rccm.200605-596OC. Epub 2006 Sep 14.

Esteban González Burchard, Luisa N Borrell, Hua Tang, Ivan Gomez, Mariam Naqvi, Sylvette Nazario, Alphonso Torres, Jesus Casal, Juan Carlos Martinez-Cruzado, Elad Ziv, Pedro C Avila, William Rodriguez-Cintron, Neil J Risch

Affiliations

Multicenter Study

Ancestry-environment interactions and asthma risk among Puerto Ricans

Shweta Choudhry et al. Am J Respir Crit Care Med. 2006.

Abstract

Background: Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, and mortality rates of any United States' population. Although socioeconomic status (SES) is negatively correlated with asthma incidence in most populations, no such relationship has been identified among Puerto Ricans. We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry.

Methods: We analyzed 135 Puerto Rican subjects with asthma and 156 control subjects recruited from six different recruitment centers in Puerto Rico. Individual ancestry for each subject was estimated using 44 ancestry informative markers. SES was assigned using the census tracts' median family income. Analyses of SES were based on the SES of the clinic site from which the subjects were recruited and on a subset of individuals on whom home address-based SES was available.

Results: In the two (independent) analyses, we found a significant interaction between SES, ancestry, and asthma disease status. At lower SES, European ancestry was associated with increased risk of asthma, whereas African ancestry was associated with decreased risk. The opposite was true for their higher SES counterparts.

Conclusions: The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry.

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Figures

<b>Figure 1.</b>

**Figure 1.

Percentage of African ancestry in Puerto Rican cases with asthma and control subjects stratified by socioeconomic status (SES). SES was obtained using clinic recruitment site address.

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References

    1. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998;351:1225–1232. - PubMed
    1. Martinez FD. Gene-environment interactions in asthma and allergies: a new paradigm to understand disease causation. Immunol Allergy Clin North Am 2005;25:709–721. - PubMed
    1. Arif AA, Delclos GL, Lee ES, Tortolero SR, Whitehead LW. Prevalence and risk factors of asthma and wheezing among US adults: an analysis of the NHANES III data. Eur Respir J 2003;21:827–833. - PubMed
    1. Akinbami LJ, Rhodes JC, Lara M. Racial and ethnic differences in asthma diagnosis among children who wheeze. Pediatrics 2005;115:1254–1260. - PubMed
    1. Beckett WS, Belanger K, Gent JF, Holford TR, Leaderer BP. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. Am J Respir Crit Care Med 1996;154:894–899. - PubMed

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