Complex modulation of cell type-specific signaling in response to type I interferons - PubMed (original) (raw)
Review
Complex modulation of cell type-specific signaling in response to type I interferons
Anette H H van Boxel-Dezaire et al. Immunity. 2006 Sep.
Free article
Abstract
The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular functions. The major signaling pathway activated by type I IFNs involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins, providing the primary mechanism through which gene expression is induced. Recent work has shown that the responses are quite complex, as shown by different responses to specific subtypes of type I IFN, activation of kinases in addition to JAKs, patterns of activation of all seven STATs in different cells, and activation of transcription factors other than STATs. The type I IFNs use this complexity to regulate many different biological functions in different types of cells, by activating different specific signals and patterns of gene expression.
Similar articles
- Mechanisms of type I interferon signaling in normal and malignant cells.
Li Y, Srivastava KK, Platanias LC. Li Y, et al. Arch Immunol Ther Exp (Warsz). 2004 May-Jun;52(3):156-63. Arch Immunol Ther Exp (Warsz). 2004. PMID: 15247882 Review. - STAT activation and differential complex formation dictate selectivity of interferon responses.
Wesoly J, Szweykowska-Kulinska Z, Bluyssen HA. Wesoly J, et al. Acta Biochim Pol. 2007;54(1):27-38. Epub 2007 Mar 9. Acta Biochim Pol. 2007. PMID: 17351669 Review. - JANUS under stress--role of JAK/STAT signaling pathway in vascular diseases.
Grote K, Luchtefeld M, Schieffer B. Grote K, et al. Vascul Pharmacol. 2005 Nov;43(5):357-63. doi: 10.1016/j.vph.2005.08.021. Epub 2005 Nov 3. Vascul Pharmacol. 2005. PMID: 16271517 Review. - Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance.
Stepkowski SM, Kirken RA. Stepkowski SM, et al. Transplantation. 2006 Aug 15;82(3):295-303. doi: 10.1097/01.tp.0000228903.03118.be. Transplantation. 2006. PMID: 16906023 Review. - Mechanisms of Type I interferon cell signaling and STAT-mediated transcriptional responses.
Lau JF, Horvath CM. Lau JF, et al. Mt Sinai J Med. 2002 May;69(3):156-68. Mt Sinai J Med. 2002. PMID: 12035075 Review.
Cited by
- CD56+ T cells inhibit HIV-1 infection of macrophages.
Hou W, Ye L, Ho WZ. Hou W, et al. J Leukoc Biol. 2012 Aug;92(2):343-51. doi: 10.1189/jlb.0312146. Epub 2012 May 16. J Leukoc Biol. 2012. PMID: 22591692 Free PMC article. - MicroRNA-155 is induced during the macrophage inflammatory response.
O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D. O'Connell RM, et al. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1604-9. doi: 10.1073/pnas.0610731104. Epub 2007 Jan 22. Proc Natl Acad Sci U S A. 2007. PMID: 17242365 Free PMC article. - Murine coronavirus delays expression of a subset of interferon-stimulated genes.
Rose KM, Elliott R, Martínez-Sobrido L, García-Sastre A, Weiss SR. Rose KM, et al. J Virol. 2010 Jun;84(11):5656-69. doi: 10.1128/JVI.00211-10. Epub 2010 Mar 31. J Virol. 2010. PMID: 20357099 Free PMC article. - T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase.
Kahler DJ, Mellor AL. Kahler DJ, et al. Handb Exp Pharmacol. 2009;(188):165-96. doi: 10.1007/978-3-540-71029-5_8. Handb Exp Pharmacol. 2009. PMID: 19031026 Free PMC article. Review. - TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma.
North CM, Kim BS, Snyder N, Crawford RB, Holsapple MP, Kaminski NE. North CM, et al. Toxicol Sci. 2009 Jan;107(1):85-92. doi: 10.1093/toxsci/kfn223. Epub 2008 Oct 22. Toxicol Sci. 2009. PMID: 18948302 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources