CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein - PubMed (original) (raw)

. 1990 Sep 21;249(4975):1431-3.

doi: 10.1126/science.1698311.

Affiliations

• PMID: 1698311
• DOI: 10.1126/science.1698311

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

S D Wright et al. Science. 1990.

Abstract

Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-alpha (TNF-alpha). Excess secretion of TNF-alpha causes endotoxic shock, an often fatal complication of infection. LPS in the bloodstream rapidly binds to the serum protein, lipopolysaccharide binding protein (LBP), and cellular responses to physiological levels of LPS are dependent on LBP. CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS. Thus, LPS may induce responses by interacting with a soluble binding protein in serum that then binds the cell surface protein CD14.

PubMed Disclaimer

Comment in

• CD14 and immune response to lipopolysaccharide.
  Maliszewski CR. Maliszewski CR. Science. 1991 May 31;252(5010):1321-2. doi: 10.1126/science.1718034. Science. 1991. PMID: 1718034 No abstract available.

Similar articles

• CD14 and other recognition molecules for lipopolysaccharide: a review.
  Kielian TL, Blecha F. Kielian TL, et al. Immunopharmacology. 1995 Apr;29(3):187-205. doi: 10.1016/0162-3109(95)00003-c. Immunopharmacology. 1995. PMID: 7542643 Review.
• Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway.
  Kitchens RL, Ulevitch RJ, Munford RS. Kitchens RL, et al. J Exp Med. 1992 Aug 1;176(2):485-94. doi: 10.1084/jem.176.2.485. J Exp Med. 1992. PMID: 1380063 Free PMC article.
• Lipopolysaccharide binding protein and CD14 in LPS dependent macrophage activation.
  Tobias PS, Ulevitch RJ. Tobias PS, et al. Immunobiology. 1993 Apr;187(3-5):227-32. doi: 10.1016/S0171-2985(11)80341-4. Immunobiology. 1993. PMID: 7687234 Review.
• Lipopolysaccharide binding protein and CD14 interaction induces tumor necrosis factor-alpha generation and neutrophil sequestration in lungs after intratracheal endotoxin.
  Ishii Y, Wang Y, Haziot A, del Vecchio PJ, Goyert SM, Malik AB. Ishii Y, et al. Circ Res. 1993 Jul;73(1):15-23. doi: 10.1161/01.res.73.1.15. Circ Res. 1993. PMID: 7685250
• Septin: a factor in plasma that opsonizes lipopolysaccharide-bearing particles for recognition by CD14 on phagocytes.
  Wright SD, Ramos RA, Patel M, Miller DS. Wright SD, et al. J Exp Med. 1992 Sep 1;176(3):719-27. doi: 10.1084/jem.176.3.719. J Exp Med. 1992. PMID: 1380975 Free PMC article.

Cited by

• Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques.
  DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC. DeBo RJ, et al. Radiat Res. 2016 Jul;186(1):55-64. doi: 10.1667/RR14357.1. Epub 2016 Jun 22. Radiat Res. 2016. PMID: 27333082 Free PMC article.
• Microbiota-based treatments in alcoholic liver disease.
  Sung H, Kim SW, Hong M, Suk KT. Sung H, et al. World J Gastroenterol. 2016 Aug 7;22(29):6673-82. doi: 10.3748/wjg.v22.i29.6673. World J Gastroenterol. 2016. PMID: 27547010 Free PMC article. Review.
• Clinical significance of monocyte heterogeneity.
  Stansfield BK, Ingram DA. Stansfield BK, et al. Clin Transl Med. 2015 Feb 14;4:5. doi: 10.1186/s40169-014-0040-3. eCollection 2015. Clin Transl Med. 2015. PMID: 25852821 Free PMC article.
• Gut Microbiota in Hypertension and Atherosclerosis: A Review.
  Verhaar BJH, Prodan A, Nieuwdorp M, Muller M. Verhaar BJH, et al. Nutrients. 2020 Sep 29;12(10):2982. doi: 10.3390/nu12102982. Nutrients. 2020. PMID: 33003455 Free PMC article. Review.
• Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus.
  Ballato E, Deepika F, Prado M, Russo V, Fuenmayor V, Bathina S, Villareal DT, Qualls C, Armamento-Villareal R. Ballato E, et al. Front Endocrinol (Lausanne). 2022 Sep 12;13:936159. doi: 10.3389/fendo.2022.936159. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36171900 Free PMC article. Clinical Trial.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal