Spreading of silent chromatin: inaction at a distance - PubMed (original) (raw)
Review
. 2006 Oct;7(10):793-803.
doi: 10.1038/nrg1920.
Affiliations
- PMID: 16983375
- DOI: 10.1038/nrg1920
Review
Spreading of silent chromatin: inaction at a distance
Paul B Talbert et al. Nat Rev Genet. 2006 Oct.
Abstract
One of the oldest unsolved problems in genetics is the observation that gene silencing can 'spread' along a chromosome. Although spreading has been widely perceived as a process of long-range assembly of heterochromatin proteins, such 'oozing' might not apply in most cases. Rather, long-range silencing seems to be a dynamic process, involving local diffusion of histone-modifying enzymes from source binding sites to low-affinity sites nearby. Discontinuous silencing might reflect looping interactions, whereas the spreading of continuous silencing might be driven by the processive movement of RNA or DNA polymerases. We review the evidence for the spreading of silencing in many contexts and organisms and conclude that multiple mechanisms have evolved that silence genes at a distance.
Similar articles
- Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers.
Adkins NL, McBryant SJ, Johnson CN, Leidy JM, Woodcock CL, Robert CH, Hansen JC, Georgel PT. Adkins NL, et al. Biochemistry. 2009 Jan 20;48(2):276-88. doi: 10.1021/bi801705g. Biochemistry. 2009. PMID: 19099415 - The many colours of chromodomains.
Brehm A, Tufteland KR, Aasland R, Becker PB. Brehm A, et al. Bioessays. 2004 Feb;26(2):133-40. doi: 10.1002/bies.10392. Bioessays. 2004. PMID: 14745831 Review. - The long and the short of it: RNA-directed chromatin asymmetry in mammalian X-chromosome inactivation.
Kanduri C, Whitehead J, Mohammad F. Kanduri C, et al. FEBS Lett. 2009 Mar 4;583(5):857-64. doi: 10.1016/j.febslet.2009.02.004. Epub 2009 Feb 8. FEBS Lett. 2009. PMID: 19302783 Review. - Slicing and spreading of heterochromatic silencing by RNA interference.
Locke SM, Martienssen RA. Locke SM, et al. Cold Spring Harb Symp Quant Biol. 2006;71:497-503. doi: 10.1101/sqb.2006.71.062. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381332 Review. - Telomeric position effect: from the yeast paradigm to human pathologies?
Ottaviani A, Gilson E, Magdinier F. Ottaviani A, et al. Biochimie. 2008 Jan;90(1):93-107. doi: 10.1016/j.biochi.2007.07.022. Epub 2007 Aug 6. Biochimie. 2008. PMID: 17868970 Review.
Cited by
- The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state.
Mukhopadhyay S, Sengupta AM. Mukhopadhyay S, et al. PLoS Comput Biol. 2013;9(7):e1003121. doi: 10.1371/journal.pcbi.1003121. Epub 2013 Jul 18. PLoS Comput Biol. 2013. PMID: 23874171 Free PMC article. - Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression.
Libbrecht MW, Ay F, Hoffman MM, Gilbert DM, Bilmes JA, Noble WS. Libbrecht MW, et al. Genome Res. 2015 Apr;25(4):544-57. doi: 10.1101/gr.184341.114. Epub 2015 Feb 12. Genome Res. 2015. PMID: 25677182 Free PMC article. - The Extended Nutrigenomics - Understanding the Interplay between the Genomes of Food, Gut Microbes, and Human Host.
Kussmann M, Van Bladeren PJ. Kussmann M, et al. Front Genet. 2011 May 20;2:21. doi: 10.3389/fgene.2011.00021. eCollection 2011. Front Genet. 2011. PMID: 22303317 Free PMC article. - Heritable epigenetic mutation of a transposon-flanked Arabidopsis gene due to lack of the chromatin-remodeling factor DDM1.
Saze H, Kakutani T. Saze H, et al. EMBO J. 2007 Aug 8;26(15):3641-52. doi: 10.1038/sj.emboj.7601788. Epub 2007 Jul 12. EMBO J. 2007. PMID: 17627280 Free PMC article. - Variation in DNA methylation of human blood over a 1-year period using the Illumina MethylationEPIC array.
Zaimi I, Pei D, Koestler DC, Marsit CJ, De Vivo I, Tworoger SS, Shields AE, Kelsey KT, Michaud DS. Zaimi I, et al. Epigenetics. 2018;13(10-11):1056-1071. doi: 10.1080/15592294.2018.1530008. Epub 2018 Oct 21. Epigenetics. 2018. PMID: 30270718 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases