Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells - PubMed (original) (raw)

. 2006 Nov;18(11):1607-13.

doi: 10.1093/intimm/dxl093. Epub 2006 Sep 20.

Affiliations

• PMID: 16987936
• DOI: 10.1093/intimm/dxl093

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells

Afonso R M Almeida et al. Int Immunol. 2006 Nov.

Abstract

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25- cells, a phenomenon termed conversion. We evaluated the relative contribution of this process to the Treg pool by transferring purified populations of CD4+ T cells into T cell-deficient mice. We report that conversion of CD25- cells into the CD4+CD25+Treg pool is minor if other bona fide CD25+ Tregs are present. Moreover, in the same hosts, the loss of CD25 expression by a population of Tregs also decreases in the presence of co-injected CD4+CD25- cells. Thus, the rate of exchange between CD25- and CD25+ T-cell populations is determined by the presence or absence of T-cell competitors. Our results attest for the role of competition in the contribution of different T-cell subsets for the regeneration of the peripheral CD4+ T-cell pool during lymphopenia.

PubMed Disclaimer

Similar articles

• Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice.
  Zhao L, Sun L, Wang H, Ma H, Liu G, Zhao Y. Zhao L, et al. J Leukoc Biol. 2007 Jun;81(6):1386-94. doi: 10.1189/jlb.0506364. Epub 2007 Mar 16. J Leukoc Biol. 2007. PMID: 17369496
• The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice.
  Qu Y, Zhang B, Zhao L, Liu G, Ma H, Rao E, Zeng C, Zhao Y. Qu Y, et al. Transpl Immunol. 2007 Apr;17(3):153-61. doi: 10.1016/j.trim.2007.01.002. Epub 2007 Jan 24. Transpl Immunol. 2007. PMID: 17331841
• CD4+ CD25+ Treg regulate the contribution of CD8+ T-cell subsets in repopulation of the lymphopenic environment.
  Almeida AR, Ciernik IF, Sallusto F, Lanzavecchia A. Almeida AR, et al. Eur J Immunol. 2010 Dec;40(12):3478-88. doi: 10.1002/eji.201040600. Epub 2010 Nov 11. Eur J Immunol. 2010. PMID: 21108468
• [CD4+CD25+Treg cell and its function in liver diseases: a review].
  Zheng MH, Zhang YC, Chen YP. Zheng MH, et al. Zhonghua Gan Zang Bing Za Zhi. 2007 Mar;15(3):238-40. Zhonghua Gan Zang Bing Za Zhi. 2007. PMID: 17407728 Review. Chinese. No abstract available.
• Regulatory cells and human cancer.
  Baecher-Allan C, Anderson DE. Baecher-Allan C, et al. Semin Cancer Biol. 2006 Apr;16(2):98-105. doi: 10.1016/j.semcancer.2005.11.003. Epub 2005 Dec 27. Semin Cancer Biol. 2006. PMID: 16378733 Review.

Cited by

• Impaired function of regulatory T cells in cord blood of children of allergic mothers.
  Hrdý J, Kocourková I, Prokešová L. Hrdý J, et al. Clin Exp Immunol. 2012 Oct;170(1):10-7. doi: 10.1111/j.1365-2249.2012.04630.x. Clin Exp Immunol. 2012. PMID: 22943196 Free PMC article.
• Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model.
  Almeida AR, Amado IF, Reynolds J, Berges J, Lythe G, Molina-París C, Freitas AA. Almeida AR, et al. Front Immunol. 2012 May 25;3:125. doi: 10.3389/fimmu.2012.00125. eCollection 2012. Front Immunol. 2012. PMID: 22654881 Free PMC article.
• GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.
  Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y. Wohlfert EA, et al. J Clin Invest. 2011 Nov;121(11):4503-15. doi: 10.1172/JCI57456. Epub 2011 Oct 3. J Clin Invest. 2011. PMID: 21965331 Free PMC article.
• c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.
  Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S. Isomura I, et al. J Exp Med. 2009 Dec 21;206(13):3001-14. doi: 10.1084/jem.20091411. Epub 2009 Dec 7. J Exp Med. 2009. PMID: 19995950 Free PMC article.
• Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.
  Wang L, de Zoeten EF, Greene MI, Hancock WW. Wang L, et al. Nat Rev Drug Discov. 2009 Dec;8(12):969-81. doi: 10.1038/nrd3031. Epub 2009 Oct 26. Nat Rev Drug Discov. 2009. PMID: 19855427 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program