Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.1038/sj.ejcn.1602525. Epub 2006 Sep 20.
B Otto, S-C Reich, M O Weickert, J Steiniger, A Machowetz, N N Rudovich, M Möhlig, N Katz, M Speth, F Meuser, J Doerfer, H-J F Zunft, A H F Pfeiffer, C Koebnick
Affiliations
- PMID: 16988651
- DOI: 10.1038/sj.ejcn.1602525
Randomized Controlled Trial
Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance
A L Garcia et al. Eur J Clin Nutr. 2007 Mar.
Abstract
Objective: Arabinoxylan (AX) consumption is associated with metabolic improvement during diabetes and with modulation of ghrelin, an orexigenic gut hormone. The effect of AX consumption on ghrelin secretion in disturbed metabolic states is unknown. Therefore, we investigated the postprandial responses to AX consumption of serum glucose, insulin and triglycerides and plasma total and acylated ghrelin in subjects with impaired glucose tolerance (IGT).
Design: Randomized, single-blind, controlled, crossover intervention trial.
Subjects: Seven female and four male adults with IGT, aged 55.5 years, and body mass index (BMI) 30.1 kg/m(2).
Intervention: Subjects received either placebo or 15 g AX supplement for 6 weeks with a 6-week washout period in-between.
Main outcome measurements: Postprandial responses of serum glucose, insulin and triglycerides, and plasma total and acylated ghrelin after a liquid meal challenge test (LMCT) measured at the beginning and at the end of the dietary intervention at -20, -5, 0, 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 min.
Results: After LMCT, AX consumption resulted in lower postprandial responses in serum glucose, insulin and triglycerides (P<0.05). Compared to placebo, total plasma ghrelin was also reduced by 42+/-8 pg/ml (P<0.001) after AX consumption with no difference in plasma acylated ghrelin.
Conclusion: AX consumption improved postprandial metabolic responses after an LMCT in subjects with IGT and reduced total ghrelin response. However, acylated ghrelin responses were unchanged, suggesting that the acylated ghrelin-mediated orexigenic regulation is not improved as only total plasma ghrelin decreased.
Similar articles
- Carob pulp preparation rich in insoluble dietary fibre and polyphenols increases plasma glucose and serum insulin responses in combination with a glucose load in humans.
Gruendel S, Otto B, Garcia AL, Wagner K, Mueller C, Weickert MO, Heldwein W, Koebnick C. Gruendel S, et al. Br J Nutr. 2007 Jul;98(1):101-5. doi: 10.1017/S0007114507701642. Epub 2007 Mar 21. Br J Nutr. 2007. PMID: 17381962 Clinical Trial. - Arabinoxylan-enriched meal increases serum ghrelin levels in healthy humans.
Möhlig M, Koebnick C, Weickert MO, Lueder W, Otto B, Steiniger J, Twilfert M, Meuser F, Pfeiffer AF, Zunft HJ. Möhlig M, et al. Horm Metab Res. 2005 May;37(5):303-8. doi: 10.1055/s-2005-861474. Horm Metab Res. 2005. PMID: 15971154 - Increased acylated plasma ghrelin, but improved lipid profiles 24-h after consumption of carob pulp preparation rich in dietary fibre and polyphenols.
Gruendel S, Garcia AL, Otto B, Wagner K, Bidlingmaier M, Burget L, Weickert MO, Dongowski G, Speth M, Katz N, Koebnick C. Gruendel S, et al. Br J Nutr. 2007 Dec;98(6):1170-7. doi: 10.1017/S0007114507777127. Epub 2007 Jul 19. Br J Nutr. 2007. PMID: 17640415 Clinical Trial. - Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research.
Koh-Banerjee P, Rimm EB. Koh-Banerjee P, et al. Proc Nutr Soc. 2003 Feb;62(1):25-9. doi: 10.1079/PNS2002232. Proc Nutr Soc. 2003. PMID: 12740053 Review. - The postprandial state: mechanisms of glucose intolerance.
Dinneen SF. Dinneen SF. Diabet Med. 1997 Aug;14 Suppl 3:S19-24. doi: 10.1002/(sici)1096-9136(199708)14:3+3.3.co;2-l. Diabet Med. 1997. PMID: 9272609 Review.
Cited by
- Gut microorganisms as promising targets for the management of type 2 diabetes.
Delzenne NM, Cani PD, Everard A, Neyrinck AM, Bindels LB. Delzenne NM, et al. Diabetologia. 2015 Oct;58(10):2206-17. doi: 10.1007/s00125-015-3712-7. Epub 2015 Jul 31. Diabetologia. 2015. PMID: 26224102 Review. - A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects.
Johansson-Persson A, Ulmius M, Cloetens L, Karhu T, Herzig KH, Onning G. Johansson-Persson A, et al. Eur J Nutr. 2014 Feb;53(1):39-48. doi: 10.1007/s00394-013-0496-8. Epub 2013 Feb 7. Eur J Nutr. 2014. PMID: 23389112 Clinical Trial. - Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice.
Neyrinck AM, Possemiers S, Druart C, Van de Wiele T, De Backer F, Cani PD, Larondelle Y, Delzenne NM. Neyrinck AM, et al. PLoS One. 2011;6(6):e20944. doi: 10.1371/journal.pone.0020944. Epub 2011 Jun 9. PLoS One. 2011. PMID: 21695273 Free PMC article. - Male grower pigs fed cereal soluble dietary fibres display biphasic glucose response and delayed glycaemic response after an oral glucose tolerance test.
Pluschke AM, Williams BA, Zhang D, Anderson ST, Roura E, Gidley MJ. Pluschke AM, et al. PLoS One. 2018 Mar 1;13(3):e0193137. doi: 10.1371/journal.pone.0193137. eCollection 2018. PLoS One. 2018. PMID: 29494594 Free PMC article. - Ghrelin, food intake, and botanical extracts: A Review.
Rezaie P, Mazidi M, Nematy M. Rezaie P, et al. Avicenna J Phytomed. 2015 Jul-Aug;5(4):271-81. Avicenna J Phytomed. 2015. PMID: 26445708 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical