Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission - PubMed (original) (raw)

. 2006 Sep 22;313(5794):1792-5.

doi: 10.1126/science.1129947.

Affiliations

• PMID: 16990550
• DOI: 10.1126/science.1129947

Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission

Yuko Fukata et al. Science. 2006.

Abstract

Abnormally synchronized synaptic transmission in the brain causes epilepsy. Most inherited forms of epilepsy result from mutations in ion channels. However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1. We show that ADAM22, a transmembrane protein that when mutated itself causes seizure, serves as a receptor for LGI1. LGI1 enhances AMPA receptor-mediated synaptic transmission in hippocampal slices. The mutated form of LGI1 fails to bind to ADAM22. ADAM22 is anchored to the postsynaptic density by cytoskeletal scaffolds containing stargazin. These studies in rat brain indicate possible avenues for understanding human epilepsy.

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Comment in

• Neuroscience. Adam finds an exciting mate.
  Snyder SH. Snyder SH. Science. 2006 Sep 22;313(5794):1744-5. doi: 10.1126/science.1133501. Science. 2006. PMID: 16990538 No abstract available.
• Glutamate receptors: finally fingered in inherited epilepsy?
  Poolos NP. Poolos NP. Epilepsy Curr. 2007 Jul-Aug;7(4):110-1. doi: 10.1111/j.1535-7511.2007.00191.x. Epilepsy Curr. 2007. PMID: 17694171 Free PMC article. No abstract available.

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