RNA polymerase II: subunit structure and function - PubMed (original) (raw)
Review
RNA polymerase II: subunit structure and function
N A Woychik et al. Trends Biochem Sci. 1990 Sep.
Abstract
RNA polymerase II is the core of the complex apparatus that is responsible for the regulated synthesis of mRNA. A comprehensive knowledge of RNA polymerase II is essential to our understanding of the molecular mechanisms through which a variety of transcription factors regulate eukaryotic gene expression. The recent cloning of genes for all ten subunits of yeast RNA polymerase II has revealed intriguing similarities and differences between the eukaryotic RNA polymerase and its simpler prokaryotic counterpart. Epitope tagging and other experiments made possible by the cloning of these genes have provided a clearer picture of RNA polymerase II subunit composition, stoichiometry and function, and set the stage for further investigating the dialogue between RNA polymerase II and transcription factors.
Similar articles
- Prokaryotic and eukaryotic RNA polymerases have homologous core subunits.
Sweetser D, Nonet M, Young RA. Sweetser D, et al. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1192-6. doi: 10.1073/pnas.84.5.1192. Proc Natl Acad Sci U S A. 1987. PMID: 3547406 Free PMC article. - Yeast RNA polymerase II subunit RPB9 is essential for growth at temperature extremes.
Woychik NA, Lane WS, Young RA. Woychik NA, et al. J Biol Chem. 1991 Oct 5;266(28):19053-5. J Biol Chem. 1991. PMID: 1918023 - Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology.
Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA. Khazak V, et al. Mol Biol Cell. 1995 Jul;6(7):759-75. doi: 10.1091/mbc.6.7.759. Mol Biol Cell. 1995. PMID: 7579693 Free PMC article. - RNA polymerase II.
Young RA. Young RA. Annu Rev Biochem. 1991;60:689-715. doi: 10.1146/annurev.bi.60.070191.003353. Annu Rev Biochem. 1991. PMID: 1883205 Review. No abstract available. - Rpb4 and Rpb7: a sub-complex integral to multi-subunit RNA polymerases performs a multitude of functions.
Sampath V, Sadhale P. Sampath V, et al. IUBMB Life. 2005 Feb;57(2):93-102. doi: 10.1080/15216540500078905. IUBMB Life. 2005. PMID: 16036568 Review.
Cited by
- Ssn6 Interacts with Polar Tube Protein 2 and Transcriptional Repressor for RNA Polymerase II: Insight into Its Involvement in the Biological Process of Microsporidium Nosema bombycis.
Wang R, Chen Y, Xu S, Wei E, He P, Wang Q, Zhang Y, Tang X, Shen Z. Wang R, et al. J Fungi (Basel). 2023 Oct 5;9(10):990. doi: 10.3390/jof9100990. J Fungi (Basel). 2023. PMID: 37888246 Free PMC article. - Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis.
Cardoso da Silva R, Vader G. Cardoso da Silva R, et al. Curr Genet. 2021 Aug;67(4):553-565. doi: 10.1007/s00294-021-01166-3. Epub 2021 Mar 12. Curr Genet. 2021. PMID: 33712914 Free PMC article. Review. - Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit.
Ream TS, Haag JR, Pontvianne F, Nicora CD, Norbeck AD, Paša-Tolić L, Pikaard CS. Ream TS, et al. Nucleic Acids Res. 2015 Apr 30;43(8):4163-78. doi: 10.1093/nar/gkv247. Epub 2015 Mar 26. Nucleic Acids Res. 2015. PMID: 25813043 Free PMC article. - Phylogenomic analyses of nuclear genes reveal the evolutionary relationships within the BEP clade and the evidence of positive selection in Poaceae.
Zhao L, Zhang N, Ma PF, Liu Q, Li DZ, Guo ZH. Zhao L, et al. PLoS One. 2013 May 29;8(5):e64642. doi: 10.1371/journal.pone.0064642. Print 2013. PLoS One. 2013. PMID: 23734211 Free PMC article. - MicroRNA: Biogenesis, Function and Role in Cancer.
Macfarlane LA, Murphy PR. Macfarlane LA, et al. Curr Genomics. 2010 Nov;11(7):537-61. doi: 10.2174/138920210793175895. Curr Genomics. 2010. PMID: 21532838 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases