The diverse functions of microRNAs in animal development and disease - PubMed (original) (raw)
Review
The diverse functions of microRNAs in animal development and disease
Wigard P Kloosterman et al. Dev Cell. 2006 Oct.
Free article
Abstract
MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in animal development and disease.
Similar articles
- MicroRNAs and apoptosis: implications in the molecular therapy of human disease.
Yang BF, Lu YJ, Wang ZG. Yang BF, et al. Clin Exp Pharmacol Physiol. 2009 Oct;36(10):951-60. doi: 10.1111/j.1440-1681.2009.05245.x. Epub 2009 Jun 29. Clin Exp Pharmacol Physiol. 2009. PMID: 19566826 Review. - MicroRNAs and their emerging roles in immunology.
Pauley KM, Chan EK. Pauley KM, et al. Ann N Y Acad Sci. 2008 Nov;1143:226-39. doi: 10.1196/annals.1443.009. Ann N Y Acad Sci. 2008. PMID: 19076353 Review. - microRNA expression in the eyes and their significance in relation to functions.
Xu S. Xu S. Prog Retin Eye Res. 2009 Mar;28(2):87-116. doi: 10.1016/j.preteyeres.2008.11.003. Epub 2008 Nov 28. Prog Retin Eye Res. 2009. PMID: 19071227 Review. - The evolution of animal microRNA function.
Niwa R, Slack FJ. Niwa R, et al. Curr Opin Genet Dev. 2007 Apr;17(2):145-50. doi: 10.1016/j.gde.2007.02.004. Epub 2007 Feb 20. Curr Opin Genet Dev. 2007. PMID: 17317150 Review. - MicroRNAs: role in cardiovascular biology and disease.
Zhang C. Zhang C. Clin Sci (Lond). 2008 Jun;114(12):699-706. doi: 10.1042/CS20070211. Clin Sci (Lond). 2008. PMID: 18474027 Review.
Cited by
- MicroRNAs--novel regulators of systemic lupus erythematosus pathogenesis.
Shen N, Liang D, Tang Y, de Vries N, Tak PP. Shen N, et al. Nat Rev Rheumatol. 2012 Dec;8(12):701-9. doi: 10.1038/nrrheum.2012.142. Epub 2012 Oct 16. Nat Rev Rheumatol. 2012. PMID: 23070646 Review. - Regulatory microRNA network identification in bovine blastocyst development.
Goossens K, Mestdagh P, Lefever S, Van Poucke M, Van Zeveren A, Van Soom A, Vandesompele J, Peelman L. Goossens K, et al. Stem Cells Dev. 2013 Jul 1;22(13):1907-20. doi: 10.1089/scd.2012.0708. Epub 2013 Mar 15. Stem Cells Dev. 2013. PMID: 23398486 Free PMC article. - Non-coding RNAs and glioma: Focus on cancer stem cells.
Rajabi A, Kayedi M, Rahimi S, Dashti F, Mirazimi SMA, Homayoonfal M, Mahdian SMA, Hamblin MR, Tamtaji OR, Afrasiabi A, Jafari A, Mirzaei H. Rajabi A, et al. Mol Ther Oncolytics. 2022 Sep 17;27:100-123. doi: 10.1016/j.omto.2022.09.005. eCollection 2022 Dec 15. Mol Ther Oncolytics. 2022. PMID: 36321132 Free PMC article. Review. - Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome.
Tao W, Dong X, Kong G, Fang P, Huang X, Bo P. Tao W, et al. Gastroenterol Res Pract. 2016;2016:9256209. doi: 10.1155/2016/9256209. Epub 2016 Aug 22. Gastroenterol Res Pract. 2016. PMID: 27635130 Free PMC article. - Micromanaging abdominal aortic aneurysms.
Maegdefessel L, Spin JM, Adam M, Raaz U, Toh R, Nakagami F, Tsao PS. Maegdefessel L, et al. Int J Mol Sci. 2013 Jul 11;14(7):14374-94. doi: 10.3390/ijms140714374. Int J Mol Sci. 2013. PMID: 23852016 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources