Paraneoplastic cerebellar degeneration: Yo-expressing tumor revealed after a 5-year follow-up with FDG-PET - PubMed (original) (raw)
Case Reports
. 2006 Dec 1;250(1-2):153-5.
doi: 10.1016/j.jns.2006.06.029. Epub 2006 Oct 2.
Affiliations
- PMID: 17011583
- DOI: 10.1016/j.jns.2006.06.029
Case Reports
Paraneoplastic cerebellar degeneration: Yo-expressing tumor revealed after a 5-year follow-up with FDG-PET
Rose Marie Mathew et al. J Neurol Sci. 2006.
Abstract
We report a patient with anti-Yo associated paraneoplastic cerebellar degeneration (PCD) whose tumor was demonstrated 5 years after developing PCD and had strong expression of Yo (cdr2) antigen. Review of this case along with clinical series and studies of tumor growth rates question the effectiveness of the anti-tumor immune response. These studies and similar cases suggest that the tumor may trigger the anti-Yo immune response at microscopic stages of development. An overwhelming majority of anti-Yo positive patients eventually develop a detectable malignancy, which argues in favor of a poorly effective or non-sustained anti-tumor immune response.
Comment in
- Anti-Yo autoimmunity; dangerous for the brain but not the tumor?
Greenlee JE. Greenlee JE. J Neurol Sci. 2006 Dec 1;250(1-2):1-2. doi: 10.1016/j.jns.2006.08.001. Epub 2006 Sep 27. J Neurol Sci. 2006. PMID: 17010383 No abstract available.
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