The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase - PubMed (original) (raw)
Comparative Study
. 1990 Dec 5;265(34):21011-5.
Affiliations
- PMID: 1701173
Free article
Comparative Study
The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase
J J Siekierka et al. J Biol Chem. 1990.
Free article
Abstract
We have recently isolated an abundant cytosolic protein from human T-cells which specifically binds the immunosuppressive agent, FK-506. The FK-506-binding protein (FKBP) is a member of a novel class of proteins possessing peptidyl-prolyl cis-trans isomerase activity. These proteins are believed to play an important role in accelerating the rate at which proteins fold into their native conformations. In the present study, we demonstrate that FKBP is not a lymphoid-specific protein, but is widely distributed and phylogenically conserved. FKBP, purified from three sources (a human T-lymphocyte cell line JURKAT, bovine calf thymus, and Saccharomyces cerevisiae) exhibit identical molecular weights, immunological cross-reactivities, and a high degree of NH2-terminal amino acid sequence homology. In addition, FKBP from all sources possesses peptidyl-prolyl cis-trans isomerase activity which can be specifically inhibited by FK-506. We conclude that FKBP may serve an important biological function in all eukaryotic cells.
Similar articles
- FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type.
Pahl A, Keller U. Pahl A, et al. J Bacteriol. 1992 Sep;174(18):5888-94. doi: 10.1128/jb.174.18.5888-5894.1992. J Bacteriol. 1992. PMID: 1381710 Free PMC article. - FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.
Wiederrecht G, Brizuela L, Elliston K, Sigal NH, Siekierka JJ. Wiederrecht G, et al. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):1029-33. doi: 10.1073/pnas.88.3.1029. Proc Natl Acad Sci U S A. 1991. PMID: 1704127 Free PMC article. - Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.
Maki N, Sekiguchi F, Nishimaki J, Miwa K, Hayano T, Takahashi N, Suzuki M. Maki N, et al. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5440-3. doi: 10.1073/pnas.87.14.5440. Proc Natl Acad Sci U S A. 1990. PMID: 1695378 Free PMC article. - Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction.
Sigal NH, Dumont FJ. Sigal NH, et al. Annu Rev Immunol. 1992;10:519-60. doi: 10.1146/annurev.iy.10.040192.002511. Annu Rev Immunol. 1992. PMID: 1375473 Review. - Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?
Sigal NH, Dumont FJ, Siekierka JJ, Wiederrecht G, Parent SA, Brizuela L. Sigal NH, et al. Transplant Proc. 1991 Dec;23(6):2846-9. Transplant Proc. 1991. PMID: 1721295 Review. No abstract available.
Cited by
- A Chemically Inducible Organelle Rerouting Assay to Probe Primary Cilium Assembly, Maintenance, and Disassembly in Cultured Cells.
Turan FB, Ercan ME, Firat-Karalar EN. Turan FB, et al. Methods Mol Biol. 2024;2725:55-78. doi: 10.1007/978-1-0716-3507-0_3. Methods Mol Biol. 2024. PMID: 37856017 - The effect of FK506 (tacrolimus) loaded with collagen membrane and fibrin glue on promotion of nerve regeneration in a rat sciatic nerve traction injury model.
Kim JH, Choi YJ, Park HI, Ahn KM. Kim JH, et al. Maxillofac Plast Reconstr Surg. 2022 Apr 6;44(1):14. doi: 10.1186/s40902-022-00339-5. Maxillofac Plast Reconstr Surg. 2022. PMID: 35384616 Free PMC article. - AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains.
Singh AK, Datta A, Jobichen C, Luan S, Vasudevan D. Singh AK, et al. Nucleic Acids Res. 2020 Feb 20;48(3):1531-1550. doi: 10.1093/nar/gkz1153. Nucleic Acids Res. 2020. PMID: 31807785 Free PMC article. - A Combined Metabolomic and Proteomic Study Revealed the Difference in Metabolite and Protein Expression Profiles in Ruminal Tissue From Goats Fed Hay or High-Grain Diets.
Guo C, Sun D, Wang X, Mao S. Guo C, et al. Front Physiol. 2019 Feb 8;10:66. doi: 10.3389/fphys.2019.00066. eCollection 2019. Front Physiol. 2019. PMID: 30800073 Free PMC article. - Inhibition and Substrate Specificity Properties of FKBP22 from a Psychrotrophic Bacterium, Shewanella sp. SIB1.
Budiman C, Lindang HU, Cheong BE, Rodrigues KF. Budiman C, et al. Protein J. 2018 Jun;37(3):270-279. doi: 10.1007/s10930-018-9772-z. Protein J. 2018. PMID: 29761378
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases