Genome-wide analysis of estrogen receptor binding sites - PubMed (original) (raw)

. 2006 Nov;38(11):1289-97.

doi: 10.1038/ng1901. Epub 2006 Oct 1.

Clifford A Meyer, Jun Song, Wei Li, Timothy R Geistlinger, Jérôme Eeckhoute, Alexander S Brodsky, Erika Krasnickas Keeton, Kirsten C Fertuck, Giles F Hall, Qianben Wang, Stefan Bekiranov, Victor Sementchenko, Edward A Fox, Pamela A Silver, Thomas R Gingeras, X Shirley Liu, Myles Brown

Affiliations

Genome-wide analysis of estrogen receptor binding sites

Jason S Carroll et al. Nat Genet. 2006 Nov.

Abstract

The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer.

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