Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-beta-lactamase, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC beta-lactamase in a Tunisian university hospital - PubMed (original) (raw)

Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-beta-lactamase, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC beta-lactamase in a Tunisian university hospital

Sonia Ktari et al. Antimicrob Agents Chemother. 2006 Dec.

Abstract

Klebsiella pneumoniae clinical isolates resistant to carbapenems were recovered from 11 patients in the hospital of Sfax, Tunisia. The isolates were closely related as shown by pulsed-field gel electrophoresis, and they produced VIM-4 metallo-enzyme, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC enzyme. The bla(VIM-4) gene is part of a class 1 integron.

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Figures

FIG. 1.

PFGE fingerprints of Klebsiella pneumoniae isolates after digestion with SpeI. Lanes: M, lambda ladder (molecular size marker; Bio-Rad); 1 to 11, PFGE patterns of imipenem-resistant Klebsiella pneumoniae isolates from Sfax University Hospital; 12, PFGE pattern of Klebsiella pneumoniae K1 isolate from Greece.

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