A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas - PubMed (original) (raw)

. 1990 Dec;348(6303):699-704.

doi: 10.1038/348699a0.

Affiliations

• PMID: 1701851
• DOI: 10.1038/348699a0

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

P Basset et al. Nature. 1990 Dec.

Abstract

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.

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