Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis - PubMed (original) (raw)
Case Reports
Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis
Philip Alex et al. Clin Rheumatol. 2007 May.
Abstract
Though the efficacy of intraarticular (IA) corticosteroid administration in the therapeutic management of rheumatoid arthritis (RA) has been well documented, its immunomodulatory effects have not been defined. Categorization of these effects is important to develop safe derivative therapeutic strategies with a more targeted mechanism of action as they relate to the pathophysiology of RA. We describe here a broad spectrum immune response to inflammation as evidenced by rapid transient systemic inhibitory effects on key inflammatory regulators induced by the effects of IA administration of triamcinolone acetonide in a case of active RA who failed to respond to methotrexate.
References
- J Rheumatol. 2004 Dec;31(12):2336-46 - PubMed
- J Clin Invest. 2004 Feb;113(4):619-27 - PubMed
- Rheumatology (Oxford). 1999 Feb;38(2):95-7 - PubMed
- Int Immunol. 1999 Jul;11(7):1139-47 - PubMed
- Semin Arthritis Rheum. 1981 May;10(4):231-54 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical