Comparison of gene expression profiles in neuropathic and inflammatory pain - PubMed (original) (raw)
Affiliations
- PMID: 17033093
Free article
Comparison of gene expression profiles in neuropathic and inflammatory pain
J Rodriguez Parkitna et al. J Physiol Pharmacol. 2006 Sep.
Free article
Abstract
Molecular mechanisms underlying the differences between chronic neuropathic and inflammatory pain are still poorly understood. Identifying those differences should provide insight into the molecular mechanism underlying features unique for neuropathic pain, such as allodynia. We have performed screening for differentially expressed genes in the spinal cord in the rat models of neuropathic and inflammatory pain. Using BD Atlas Rat 4K arrays we found several differences in expression of secretion-related genes between inflammatory and neuropathic pain. Development of the latter was characterized by up-regulated expression of genes associated with immune response and microglia activation and also, to a lesser extent, with cytoskeleton rearrangement. The relative increase in abundance of four genes, intercellular adhesion molecule 1 (ICAM-1), calcitonin gene related peptide (CGRP), tissue inhibitor of metalloproteinase 1 (TIMP-1), chemokine-like receptor 1 was confirmed by reverse transcription Real-Time PCR (qPCR) validation in the spinal cord in neuropathic pain. Levels of transcripts corresponding to ICAM-1 and TIMP-1 were also increased in the dorsal root ganglia (DRG) of neuropathic rats. Our data point at the importance of immune response- and microglia activation-related genes in the development of chronic neuropathic pain, and suggest that expression of CGRP gene in the dorsal horn of the spinal cord could be involved in persistence of its symptoms.
Similar articles
- Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2.
Abbadie C, Lindia JA, Cumiskey AM, Peterson LB, Mudgett JS, Bayne EK, DeMartino JA, MacIntyre DE, Forrest MJ. Abbadie C, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7947-52. doi: 10.1073/pnas.1331358100. Epub 2003 Jun 13. Proc Natl Acad Sci U S A. 2003. PMID: 12808141 Free PMC article. - Long-lasting regulation of galanin, opioid, and other peptides in dorsal root ganglia and spinal cord during experimental polyarthritis.
Calzà L, Pozza M, Arletti R, Manzini E, Hökfelt T. Calzà L, et al. Exp Neurol. 2000 Aug;164(2):333-43. doi: 10.1006/exnr.2000.7442. Exp Neurol. 2000. PMID: 10915572 - Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain.
Okuse K, Chaplan SR, McMahon SB, Luo ZD, Calcutt NA, Scott BP, Akopian AN, Wood JN. Okuse K, et al. Mol Cell Neurosci. 1997;10(3-4):196-207. doi: 10.1006/mcne.1997.0657. Mol Cell Neurosci. 1997. PMID: 9532581 - [Contribution of primary sensory neurons and spinal glial cells to pathomechanisms of neuropathic pain].
Obata K, Noguchi K. Obata K, et al. Brain Nerve. 2008 May;60(5):483-92. Brain Nerve. 2008. PMID: 18516970 Review. Japanese. - Immune and inflammatory mechanisms in neuropathic pain.
Moalem G, Tracey DJ. Moalem G, et al. Brain Res Rev. 2006 Aug;51(2):240-64. doi: 10.1016/j.brainresrev.2005.11.004. Epub 2006 Jan 4. Brain Res Rev. 2006. PMID: 16388853 Review.
Cited by
- Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets.
Lakhan SE, Avramut M. Lakhan SE, et al. Pain Res Treat. 2012;2012:952906. doi: 10.1155/2012/952906. Epub 2012 Aug 28. Pain Res Treat. 2012. PMID: 22970361 Free PMC article. - Central sensitization: a generator of pain hypersensitivity by central neural plasticity.
Latremoliere A, Woolf CJ. Latremoliere A, et al. J Pain. 2009 Sep;10(9):895-926. doi: 10.1016/j.jpain.2009.06.012. J Pain. 2009. PMID: 19712899 Free PMC article. Review. - Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory.
Yukhananov R, Kissin I. Yukhananov R, et al. BMC Neurosci. 2008 Mar 13;9:32. doi: 10.1186/1471-2202-9-32. BMC Neurosci. 2008. PMID: 18366630 Free PMC article. - Long-Term Anti-Allodynic Effect of Immediate Pulsed Radiofrequency Modulation through Down-Regulation of Insulin-Like Growth Factor 2 in a Neuropathic Pain Model.
Yeh CC, Sun HL, Huang CJ, Wong CS, Cherng CH, Huh BK, Wang JS, Chien CC. Yeh CC, et al. Int J Mol Sci. 2015 Nov 13;16(11):27156-70. doi: 10.3390/ijms161126013. Int J Mol Sci. 2015. PMID: 26580597 Free PMC article. - Mas-related G-protein-coupled receptors inhibit pathological pain in mice.
Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X. Guan Y, et al. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15933-8. doi: 10.1073/pnas.1011221107. Epub 2010 Aug 19. Proc Natl Acad Sci U S A. 2010. PMID: 20724664 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous