Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues - PubMed (original) (raw)

. 1991 Feb;138(2):385-93.

Affiliations

PMID: 1704191
PMCID: PMC1886196

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues

G E Rice et al. Am J Pathol. 1991 Feb.

Abstract

Inducible cell adhesion molecule 110 (INCAM-110), is a 110-kd adhesion receptor for lymphocytes and monocytes identified on cytokine-activated endothelium. Using immunoperoxidase techniques, little or no INCAM-110 was detected on endothelium in normal human tissues. In contrast, INCAM-110 was expressed in postcapillary venules in a variety of active inflammatory processes. In acute appendicitis, INCAM-110 was found coincident with strong expression of endothelial leukocyte adhesion molecule 1 (ELAM-1), a cytokine-inducible molecule that functions in neutrophil adhesion. However, in certain chronic inflammatory processes (eg, sarcoidosis), INCAM-110 was observed without simultaneous ELAM-1 expression. Anti-INCAM-110 antibody E1/6 also marked several extravascular cell types, including lymphoid dendritic cells, some tissue macrophages, synovial lining cells, and reactive mesothelial cells. These data suggest a role for endothelial INCAM-110 in the pathophysiology of both acute and chronic inflammatory reactions. Furthermore INCAM-110 may function as an adhesion molecule for mononuclear leukocytes in a variety of extravascular sites.

PubMed Disclaimer

Cited by

Predictive Value of High ICAM-1 Level for Poor Treatment Response to Low-Dose Decitabine in Adult Corticosteroid Resistant ITP Patients.
Li C, Li L, Sun M, Sun J, Shao L, Xu M, Hou Y, Peng J, Wang L, Hou M. Li C, et al. Front Immunol. 2021 Jul 13;12:689663. doi: 10.3389/fimmu.2021.689663. eCollection 2021. Front Immunol. 2021. PMID: 34326842 Free PMC article.
VCAM-1 Upregulation Contributes to Insensitivity of Vemurafenib in BRAF-Mutant Thyroid Cancer.
Chen S, Su X, Jiang X, Zhang T, Min I, Ding Y, Wang X, Mao Z, Cao J, Teng X, Fahey TJ 3rd, Wang W, Teng L. Chen S, et al. Transl Oncol. 2020 Feb;13(2):441-451. doi: 10.1016/j.tranon.2019.10.007. Epub 2020 Jan 3. Transl Oncol. 2020. PMID: 31911278 Free PMC article.
Characterization of Biomarker Levels in Crimean-Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome.
Korva M, Rus KR, Pavletič M, Saksida A, Knap N, Jelovšek M, Smrdel KS, Jakupi X, Humolli I, Dedushaj J, Petrovec M, Avšič-Županc T. Korva M, et al. Viruses. 2019 Jul 26;11(8):686. doi: 10.3390/v11080686. Viruses. 2019. PMID: 31357521 Free PMC article.
The "Intermediate" CD14++CD16+ monocyte subset increases in severe peripheral artery disease in humans.
Wildgruber M, Aschenbrenner T, Wendorff H, Czubba M, Glinzer A, Haller B, Schiemann M, Zimmermann A, Berger H, Eckstein HH, Meier R, Wohlgemuth WA, Libby P, Zernecke A. Wildgruber M, et al. Sci Rep. 2016 Dec 19;6:39483. doi: 10.1038/srep39483. Sci Rep. 2016. PMID: 27991581 Free PMC article.
Serum levels of soluble vascular cell adhesion molecules may correlate with the severity of dengue virus-1 infection in adults.
Liao B, Tang Y, Hu F, Zhou W, Yao X, Hong W, Wang J, Zhang X, Tang X, Zhang F. Liao B, et al. Emerg Microbes Infect. 2015 Apr;4(4):e24. doi: 10.1038/emi.2015.24. Epub 2015 Apr 22. Emerg Microbes Infect. 2015. PMID: 26421267 Free PMC article.

References

1. J Immunol. 1986 Jan;136(1):203-7 - PubMed
1. J Cell Physiol. 1988 Nov;137(2):305-9 - PubMed
1. Science. 1989 Mar 3;243(4895):1160-5 - PubMed
1. Cell. 1989 Jan 13;56(1):37-46 - PubMed
1. Am J Pathol. 1988 Dec;133(3):426-33 - PubMed

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues - PubMed (original) (raw)