Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder - PubMed (original) (raw)
Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder
Michael Kluge et al. J Psychiatr Res. 2007 Dec.
Abstract
Information on the function of the hypothalamic-pituitary-adrenal (HPA) axis, the main mammalian system of stress response, in obsessive compulsive disorder (OCD) is inconsistent. In this study, nine inpatients with a DSM-IV diagnosis of OCD without comorbid major depression (Yale-Brown Obsessive Compulsive Scale [Y-BOCS] score >15; HAMD-21 total score 16) and nine healthy matched controls were included. Blood of patients (seven males; 31.8 +/- 9.3 years, Y-BOCS: 27.3 +/- 4.3, HAMD-21: 13.3 +/-1.9) and controls (seven males, 31.6 +/- 9.1 years) was drawn every 20 min between 23:00 and 7:00 h during sleep using a long catheter for later ACTH and cortisol analysis. Secretion patterns of cortisol and ACTH were similar in both groups, in OCD, however, at a higher level. Area under the curve plasma concentrations of both ACTH (p<0.05) and cortisol (p<0.005) were significantly greater in patients with OCD (ACTH: 674.3 +/- 57.4; cortisol: 2148.4 +/-271.7) than in controls (ACTH: 460.2 +/- 61.0; cortisol: 1191.2 +/- 124.1). In conclusion, our findings suggest that the activity of the HPA axis in patients with OCD is increased compared to healthy controls.
Similar articles
- Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder.
Kluge M, Schüssler P, Weikel J, Dresler M, Zuber V, Querfurt F, Yassouridis A, Steiger A. Kluge M, et al. Psychoneuroendocrinology. 2006 Oct;31(9):1098-104. doi: 10.1016/j.psyneuen.2006.07.002. Epub 2006 Sep 11. Psychoneuroendocrinology. 2006. PMID: 16965859 - Evidence of basal pituitary-adrenal overactivity in first episode, drug naïve patients with schizophrenia.
Ryan MC, Sharifi N, Condren R, Thakore JH. Ryan MC, et al. Psychoneuroendocrinology. 2004 Sep;29(8):1065-70. doi: 10.1016/j.psyneuen.2003.08.011. Psychoneuroendocrinology. 2004. PMID: 15219658 Clinical Trial. - Diurnal cortisol levels and cortisol response in youths with obsessive-compulsive disorder.
Gustafsson PE, Gustafsson PA, Ivarsson T, Nelson N. Gustafsson PE, et al. Neuropsychobiology. 2008;57(1-2):14-21. doi: 10.1159/000123117. Epub 2008 Apr 18. Neuropsychobiology. 2008. PMID: 18424906 - HPA axis activity in patients with panic disorder: review and synthesis of four studies.
Abelson JL, Khan S, Liberzon I, Young EA. Abelson JL, et al. Depress Anxiety. 2007;24(1):66-76. doi: 10.1002/da.20220. Depress Anxiety. 2007. PMID: 16845643 Review. - Neuroendocrine dysregulation in primary insomnia.
Rodenbeck A, Hajak G. Rodenbeck A, et al. Rev Neurol (Paris). 2001 Nov;157(11 Pt 2):S57-61. Rev Neurol (Paris). 2001. PMID: 11924040 Review.
Cited by
- Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway.
Vallée A, Lecarpentier Y, Vallée JN. Vallée A, et al. Mol Psychiatry. 2022 Jan;27(1):230-248. doi: 10.1038/s41380-021-01086-1. Epub 2021 Apr 9. Mol Psychiatry. 2022. PMID: 33837269 Review. - Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates.
Cirulli F, Francia N, Berry A, Aloe L, Alleva E, Suomi SJ. Cirulli F, et al. Neurosci Biobehav Rev. 2009 Apr;33(4):573-85. doi: 10.1016/j.neubiorev.2008.09.001. Epub 2008 Sep 4. Neurosci Biobehav Rev. 2009. PMID: 18817811 Free PMC article. Review. - Central serotonin transporter levels are associated with stress hormone response and anxiety.
Reimold M, Knobel A, Rapp MA, Batra A, Wiedemann K, Ströhle A, Zimmer A, Schönknecht P, Smolka MN, Weinberger DR, Goldman D, Machulla HJ, Bares R, Heinz A. Reimold M, et al. Psychopharmacology (Berl). 2011 Feb;213(2-3):563-72. doi: 10.1007/s00213-010-1903-y. Epub 2010 Jun 29. Psychopharmacology (Berl). 2011. PMID: 20585760 Free PMC article. - Perceived Stress in Obsessive-Compulsive Disorder is Related with Obsessive but Not Compulsive Symptoms.
Morgado P, Freitas D, Bessa JM, Sousa N, Cerqueira JJ. Morgado P, et al. Front Psychiatry. 2013 Apr 2;4:21. doi: 10.3389/fpsyt.2013.00021. eCollection 2013. Front Psychiatry. 2013. PMID: 23565098 Free PMC article. - Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series.
Fornaro M. Fornaro M. Ann Gen Psychiatry. 2011 Feb 28;10(1):5. doi: 10.1186/1744-859X-10-5. Ann Gen Psychiatry. 2011. PMID: 21356085 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical