Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice - PubMed (original) (raw)
. 2006 Dec 15;281(50):38440-7.
doi: 10.1074/jbc.M606736200. Epub 2006 Oct 18.
Affiliations
- PMID: 17050533
- DOI: 10.1074/jbc.M606736200
Free article
Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice
Charlene Supnet et al. J Biol Chem. 2006.
Free article
Abstract
Disruption of intracellular calcium homeostasis precedes the neurodegeneration that occurs in Alzheimer disease (AD). Of the many neuronal calcium-regulating proteins, we focused on endoplasmic reticulum (ER)-resident ryanodine receptors (RyRs) because they are increased in the hippocampus of mice expressing mutant presenilin-1 and are associated with neurotoxicity. Others have observed that ryanodine binding is elevated in human postmortem hippocampal regions suggesting that RyR(s) are involved in AD pathogenesis. Here we report that extracellular amyloid-beta(Abeta)-(1-42) specifically increased RyR-3, but not RyR-1 or RyR-2, gene expression in cortical neurons from C57Bl6 mice. Furthermore, endogenously produced Abeta-(1-42) increased RyR-3 mRNA and protein in cortical neurons from transgenic (Tg)CRND8 mice, a mouse model of AD. Increased RyR-3 mRNA and protein was also observed in brain tissue from 4- to 4.5-month-old Tg animals compared with non-Tg littermate controls. In experiments performed in nominal extracellular calcium, neurons from Tg mice had significant increases in intracellular calcium following ryanodine or glutamate treatment compared with littermate controls, which was abolished by treatment with small interfering RNA directed to RyR-3, indicating that the higher levels of calcium originated from RyR-3-regulated stores. Taken together, these observations suggest that Abeta-(1-42)-mediated changes in intracellular calcium homeostasis is regulated in part through a direct increase of RyR-3 expression and function.
Similar articles
- Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M. Oulès B, et al. J Neurosci. 2012 Aug 22;32(34):11820-34. doi: 10.1523/JNEUROSCI.0875-12.2012. J Neurosci. 2012. PMID: 22915123 Free PMC article. - Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
Wu B, Yamaguchi H, Lai FA, Shen J. Wu B, et al. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15091-6. doi: 10.1073/pnas.1304171110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918386 Free PMC article. - Ryanodine receptors: physiological function and deregulation in Alzheimer disease.
Del Prete D, Checler F, Chami M. Del Prete D, et al. Mol Neurodegener. 2014 Jun 5;9:21. doi: 10.1186/1750-1326-9-21. Mol Neurodegener. 2014. PMID: 24902695 Free PMC article. Review. - Neuronal Ryanodine Receptors in Development and Aging.
Abu-Omar N, Das J, Szeto V, Feng ZP. Abu-Omar N, et al. Mol Neurobiol. 2018 Feb;55(2):1183-1192. doi: 10.1007/s12035-016-0375-4. Epub 2017 Jan 19. Mol Neurobiol. 2018. PMID: 28102470 Review.
Cited by
- Role of presenilins in neuronal calcium homeostasis.
Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Zhang H, et al. J Neurosci. 2010 Jun 23;30(25):8566-80. doi: 10.1523/JNEUROSCI.1554-10.2010. J Neurosci. 2010. PMID: 20573903 Free PMC article. - Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease.
Hashimoto S, Saido TC. Hashimoto S, et al. Open Biol. 2018 Apr;8(4):180024. doi: 10.1098/rsob.180024. Open Biol. 2018. PMID: 29695619 Free PMC article. Review. - Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.
Kam TI, Gwon Y, Jung YK. Kam TI, et al. Cell Mol Life Sci. 2014 Dec;71(24):4803-13. doi: 10.1007/s00018-014-1706-0. Epub 2014 Aug 24. Cell Mol Life Sci. 2014. PMID: 25151011 Free PMC article. Review. - Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.
Koran ME, Hohman TJ, Thornton-Wells TA. Koran ME, et al. Hum Genet. 2014 Jan;133(1):85-93. doi: 10.1007/s00439-013-1354-8. Epub 2013 Sep 12. Hum Genet. 2014. PMID: 24026422 Free PMC article. - New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
Corona C, Pensalfini A, Frazzini V, Sensi SL. Corona C, et al. Cell Death Dis. 2011 Jun 23;2(6):e176. doi: 10.1038/cddis.2011.57. Cell Death Dis. 2011. PMID: 21697951 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous