Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia - PubMed (original) (raw)
Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia
Linda S Wood et al. Biol Psychiatry. 2007.
Abstract
Background: Schizophrenia is a complex psychiatric disorder with a strong genetic component. Past linkage studies have implicated several chromosomal regions in the etiology of schizophrenia. Within these regions, several genes have been identified via candidate gene association studies as strong schizophrenia susceptibility loci, including DAO, DAOA, DISC1, DTNBP1, and RGS4.
Methods: The present study attempted to replicate these association findings by analyzing a total of 120 markers across these genes in 311 schizophrenia subjects, 140 schizoaffective subjects, and 291 control subjects.
Results: Our study found no association for DAOA and DTNBP1 with schizophrenia. Although no association was seen with DAOA and DTNBP1, several other markers in the other genes resulted in significant association with schizophrenia (p < .05). However, after a conservative Bonferroni correction for multiple testing, only one marker, rs3918346, within DAO remained significant (odds ratio = 1.71, confidence interval = 1.32-2.22, p = 4 x 10(-5)). This significant association was concordant with previous DAO genetic findings.
Conclusions: Our results significantly support DAO as a susceptibility locus for schizophrenia and offer some support for the implication of both RGS4 and DISC1 in the etiology of schizophrenia. However, we see no evidence to support either DAOA or DTNBP1 as schizophrenia disease loci.
Similar articles
- Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction.
Vilella E, Costas J, Sanjuan J, Guitart M, De Diego Y, Carracedo A, Martorell L, Valero J, Labad A, De Frutos R, Nájera C, Moltó MD, Toirac I, Guillamat R, Brunet A, Vallès V, Pérez L, Leon M, de Fonseca FR, Phillips C, Torres M. Vilella E, et al. J Psychiatr Res. 2008 Mar;42(4):278-88. doi: 10.1016/j.jpsychires.2007.02.005. Epub 2007 Apr 3. J Psychiatr Res. 2008. PMID: 17408693 - DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study.
Jönsson EG, Saetre P, Vares M, Andreou D, Larsson K, Timm S, Rasmussen HB, Djurovic S, Melle I, Andreassen OA, Agartz I, Werge T, Hall H, Terenius L. Jönsson EG, et al. Neuropsychobiology. 2009;59(3):142-50. doi: 10.1159/000218076. Epub 2009 May 12. Neuropsychobiology. 2009. PMID: 19439994 - D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia.
Corvin A, Donohoe G, McGhee K, Murphy K, Kenny N, Schwaiger S, Nangle JM, Morris D, Gill M. Corvin A, et al. Neurosci Lett. 2007 Oct 16;426(2):97-100. doi: 10.1016/j.neulet.2007.09.002. Epub 2007 Sep 8. Neurosci Lett. 2007. PMID: 17890006 - Schizophrenia: genes at last?
Owen MJ, Craddock N, O'Donovan MC. Owen MJ, et al. Trends Genet. 2005 Sep;21(9):518-25. doi: 10.1016/j.tig.2005.06.011. Trends Genet. 2005. PMID: 16009449 Review. - Recent advances in the genetics of schizophrenia.
O'Donovan MC, Williams NM, Owen MJ. O'Donovan MC, et al. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R125-33. doi: 10.1093/hmg/ddg302. Epub 2003 Sep 2. Hum Mol Genet. 2003. PMID: 12952866 Review.
Cited by
- The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
Riley B, Kuo PH, Maher BS, Fanous AH, Sun J, Wormley B, O'Neill FA, Walsh D, Zhao Z, Kendler KS. Riley B, et al. Schizophr Res. 2009 Dec;115(2-3):245-53. doi: 10.1016/j.schres.2009.09.008. Epub 2009 Oct 2. Schizophr Res. 2009. PMID: 19800201 Free PMC article. - DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene.
Duan J, Martinez M, Sanders AR, Hou C, Burrell GJ, Krasner AJ, Schwartz DB, Gejman PV. Duan J, et al. Hum Hered. 2007;64(2):97-106. doi: 10.1159/000101961. Epub 2007 May 2. Hum Hered. 2007. PMID: 17476109 Free PMC article. - Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population.
Xu FL, Yao J, Wu X, Xia X, Xing JX, Xuan JF, Liu YP, Wang BJ. Xu FL, et al. Neuropsychiatr Dis Treat. 2020 Apr 16;16:985-992. doi: 10.2147/NDT.S250282. eCollection 2020. Neuropsychiatr Dis Treat. 2020. PMID: 32346293 Free PMC article. - Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study.
Habl G, Zink M, Petroianu G, Bauer M, Schneider-Axmann T, von Wilmsdorff M, Falkai P, Henn FA, Schmitt A. Habl G, et al. J Neural Transm (Vienna). 2009 Dec;116(12):1657-65. doi: 10.1007/s00702-009-0312-z. Epub 2009 Oct 13. J Neural Transm (Vienna). 2009. PMID: 19823762 Free PMC article. - Association of variants in DISC1 with psychosis-related traits in a large population cohort.
Tomppo L, Hennah W, Miettunen J, Järvelin MR, Veijola J, Ripatti S, Lahermo P, Lichtermann D, Peltonen L, Ekelund J. Tomppo L, et al. Arch Gen Psychiatry. 2009 Feb;66(2):134-41. doi: 10.1001/archgenpsychiatry.2008.524. Arch Gen Psychiatry. 2009. PMID: 19188535 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous