Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor - PubMed (original) (raw)

. 2006 Nov 13:(42):4372-4.

doi: 10.1039/b612154c. Epub 2006 Sep 29.

Affiliations

• PMID: 17057847
• DOI: 10.1039/b612154c

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor

Bhagavathy Shanmugasundaram et al. Chem Commun (Camb). 2006.

Abstract

Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

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