Polycomb silencers control cell fate, development and cancer - PubMed (original) (raw)

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doi: 10.1038/nrc1991.

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• PMID: 17060944
• DOI: 10.1038/nrc1991

Review

Polycomb silencers control cell fate, development and cancer

Anke Sparmann et al. Nat Rev Cancer. 2006 Nov.

Abstract

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.

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