Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury - PubMed (original) (raw)

doi: 10.1189/jlb.0706468. Epub 2006 Oct 24.

Affiliations

PMID: 17062605
DOI: 10.1189/jlb.0706468

Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury

Allan Tsung et al. J Leukoc Biol. 2007 Jan.

Abstract

Endogenous ligands released from damaged cells, so-called damage-associated molecular pattern molecules (DAMPs), activate innate signaling pathways including the TLRs. We have shown that hepatic, warm ischemia and reperfusion (I/R) injury, generating local, noninfectious DAMPs, promotes inflammation, which is largely TLR4-dependent. Here, we demonstrate that increasing dendritic cell (DC) numbers enhance inflammation and organ injury after hepatic I/R. High-mobility group box 1 (HMGB1), a NF released by necrotic cells or secreted by stimulated cells, is one of a number of ligands promoting TLR4 reactivity. Augmentation of DC numbers in the liver with GM-CSF hydrodynamic transfection significantly increased liver damage after I/R when compared with controls. TLR4 engagement on hepatic DC was required for the I/R-induced injury, as augmentation of DC numbers in TLR4 mutant (C3H/HeJ) mice did not worsen hepatic damage. It is interesting that TLR4 expression was increased in hepatic DC following HMGB1 stimulation in vitro, suggesting a mechanism for the increased liver injury following I/R. It thus appears that functional TLR4 on DC is required for I/R-induced injury. Furthermore, HMGB1 may direct the inflammatory responses mediated by DC, at least in part, by enhancing TLR4 expression and reactivity to it and other DAMPs.

PubMed Disclaimer

Cited by

Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning.
Xiao F, Huang G, Yuan G, Li S, Wang Y, Tan Z, Liu Z, Tomlinson S, He S, Ouyang G, Zeng Y. Xiao F, et al. Front Immunol. 2024 Apr 16;15:1372441. doi: 10.3389/fimmu.2024.1372441. eCollection 2024. Front Immunol. 2024. PMID: 38690269 Free PMC article.
Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice.
Xie G, Zhang Q, Fang Z, Che L, Lin Y, Xu S, Zhuo Y, Hua L, Jiang X, Li J, Sun M, Zou Y, Huang C, Li L, Wu D, Feng B. Xie G, et al. Antioxidants (Basel). 2023 Jun 28;12(7):1355. doi: 10.3390/antiox12071355. Antioxidants (Basel). 2023. PMID: 37507895 Free PMC article.
Lipid-based regulators of immunity.
Johnson WT, Dorn NC, Ogbonna DA, Bottini N, Shah NJ. Johnson WT, et al. Bioeng Transl Med. 2021 Dec 31;7(2):e10288. doi: 10.1002/btm2.10288. eCollection 2022 May. Bioeng Transl Med. 2021. PMID: 35600637 Free PMC article. Review.
The exogenous delivery of microRNA-449b-5p using spermidine-PLGA nanoparticles efficiently decreases hepatic injury.
Hu F, Yang D, Qian B, Fan S, Zhu Q, Ren H, Li X, Zhai B. Hu F, et al. RSC Adv. 2019 Oct 30;9(60):35135-35144. doi: 10.1039/c9ra06129k. eCollection 2019 Oct 28. RSC Adv. 2019. PMID: 35530696 Free PMC article.
Single-cell profiling reveals distinct immune phenotypes that contribute to ischaemia-reperfusion injury after steatotic liver transplantation.
Yang X, Lu D, Wang R, Lian Z, Lin Z, Zhuo J, Chen H, Yang M, Tan W, Yang M, Wei X, Wei Q, Zheng S, Xu X. Yang X, et al. Cell Prolif. 2021 Oct;54(10):e13116. doi: 10.1111/cpr.13116. Epub 2021 Sep 1. Cell Prolif. 2021. PMID: 34469018 Free PMC article.

Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury - PubMed (original) (raw)