DTNBP1 genotype influences cognitive decline in schizophrenia - PubMed (original) (raw)

DTNBP1 genotype influences cognitive decline in schizophrenia

Katherine E Burdick et al. Schizophr Res. 2007 Jan.

Abstract

Objective: Intellectual decline is common in schizophrenia and predicts functional outcome. While many patients undergo intellectual decline that typically predates the onset of symptoms, few studies have investigated the underlying mechanism through which this occurs. The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).

Methods: We assessed cognitive decline in 183 Caucasian patients with schizophrenia using a proxy measure of premorbid IQ with which current general cognitive ability (g) was compared. We then tested for a relationship between the risk haplotype identified in previous work (CTCTAC) and intellectual decline.

Results: We found that carriers of the CTCTAC haplotype, demonstrated a significantly greater decline in IQ as compared with non-carriers (p=0.05).

Conclusions: These data suggest that DTNBP1 influences the severity of intellectual decline in schizophrenia and may represent one underlying cause for heterogeneity in cognitive course.

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Figures

Figure 1. Intellectual Decline in Patients with Schizophrenia by DTNBP1 Genotype

Carriers of the CTCTAC risk haplotype demonstrate a greater intellectual decline than non-carriers. The data represent residual scores (observed minus predicted IQ) and are presented on the y-axis as Standard Scores (with a mean of 100 and a standard deviation of 15). The x-axis illustrates change from predicted IQ to current IQ in carriers versus non-carriers.

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DTNBP1 genotype influences cognitive decline in schizophrenia - PubMed (original) (raw)