Why pain gets worse: the mechanism of heat hyperalgesia - PubMed (original) (raw)
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Why pain gets worse: the mechanism of heat hyperalgesia
Xuming Zhang et al. J Gen Physiol. 2006 Nov.
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- Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.
Stein AT, Ufret-Vincenty CA, Hua L, Santana LF, Gordon SE. Stein AT, et al. J Gen Physiol. 2006 Nov;128(5):509-22. doi: 10.1085/jgp.200609576. J Gen Physiol. 2006. PMID: 17074976 Free PMC article.
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References
- Bhave, G., W. Zhu, H. Wang, D.J. Brasier, G.S. Oxford, and R.W. Gereau. 2002. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron. 35:721–731. - PubMed
- Bron, R., L.J. Klesse, K. Shah, L.F. Parada, and J. Winter. 2003. Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol. Cell. Neurosci. 22:118–132. - PubMed
- Caterina, M.J., M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius. 1997. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389:816–824. - PubMed
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