Molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers - PubMed (original) (raw)

Review

. 2006 Dec 15;281(50):38117-21.

doi: 10.1074/jbc.R600025200. Epub 2006 Nov 2.

Affiliations

• PMID: 17082192
• DOI: 10.1074/jbc.R600025200

Free article

Review

Molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers

Jamshid Khoshnoodi et al. J Biol Chem. 2006.

Free article

Abstract

The alpha-chains of the collagen superfamily are encoded with information that specifies self-assembly into fibrils, microfibrils, and networks that have diverse functions in the extracellular matrix. A key self-organizing step, common to all collagen types, is trimerization that selects, binds, and registers cognate alpha-chains for assembly of triple helical protomers that subsequently oligomerize into specific suprastructures. In this article, we review recent findings on the mechanism of chain selection and infer that terminal noncollagenous domains function as recognition modules in trimerization and are therefore key determinants of specificity in the assembly of suprastructures. This mechanism is also illustrated with computer-generated animations.

PubMed Disclaimer

Similar articles

• Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains.
  Boutaud A, Borza DB, Bondar O, Gunwar S, Netzer KO, Singh N, Ninomiya Y, Sado Y, Noelken ME, Hudson BG. Boutaud A, et al. J Biol Chem. 2000 Sep 29;275(39):30716-24. doi: 10.1074/jbc.M004569200. J Biol Chem. 2000. PMID: 10896941
• The N-terminal N5 subdomain of the alpha 3(VI) chain is important for collagen VI microfibril formation.
  Fitzgerald J, Mörgelin M, Selan C, Wiberg C, Keene DR, Lamandé SR, Bateman JF. Fitzgerald J, et al. J Biol Chem. 2001 Jan 5;276(1):187-93. doi: 10.1074/jbc.M008173200. J Biol Chem. 2001. PMID: 11027693
• The crucial role of trimerization domains in collagen folding.
  Boudko SP, Engel J, Bächinger HP. Boudko SP, et al. Int J Biochem Cell Biol. 2012 Jan;44(1):21-32. doi: 10.1016/j.biocel.2011.09.009. Epub 2011 Oct 5. Int J Biochem Cell Biol. 2012. PMID: 22001560 Review.
• Collagens as multidomain proteins.
  van der Rest M, Garrone R. van der Rest M, et al. Biochimie. 1990 Jun-Jul;72(6-7):473-84. doi: 10.1016/0300-9084(90)90071-n. Biochimie. 1990. PMID: 2257280 Review.
• Trimerization and triple helix stabilization of the collagen XIX NC2 domain.
  Boudko SP, Engel J, Bächinger HP. Boudko SP, et al. J Biol Chem. 2008 Dec 5;283(49):34345-51. doi: 10.1074/jbc.M806352200. Epub 2008 Oct 8. J Biol Chem. 2008. PMID: 18845531 Free PMC article.

Cited by

• A founder COL4A3 pathogenic variant resulting in Alport syndrome and thin basement membrane disease: a case report series.
  Tkemaladze T, Bregvadze K, Kvaratskhelia E, Abzianidze E, Davitaia T. Tkemaladze T, et al. Front Med (Lausanne). 2023 Dec 21;10:1281049. doi: 10.3389/fmed.2023.1281049. eCollection 2023. Front Med (Lausanne). 2023. PMID: 38188341 Free PMC article.
• The Phenotypic Spectrum of COL4A3 Heterozygotes.
  Solanki KV, Hu Y, Moore BS, Abedi V, Avula V, Mirshahi T; Regeneron Genetics Center; Strande NT, Bucaloiu ID, Chang AR. Solanki KV, et al. Kidney Int Rep. 2023 Jul 25;8(10):2088-2099. doi: 10.1016/j.ekir.2023.07.010. eCollection 2023 Oct. Kidney Int Rep. 2023. PMID: 37849993 Free PMC article.
• Genetic and molecular dynamics analysis of two variants of the COL4A5 gene causing Alport syndrome.
  Liang L, Wu H, Cai Z, Zhao J. Liang L, et al. BMC Med Genomics. 2023 Aug 18;16(1):192. doi: 10.1186/s12920-023-01623-7. BMC Med Genomics. 2023. PMID: 37596645 Free PMC article.
• Methadone alters transcriptional programs associated with synapse formation in human cortical organoids.
  Dwivedi I, Caldwell AB, Zhou D, Wu W, Subramaniam S, Haddad GG. Dwivedi I, et al. Transl Psychiatry. 2023 May 6;13(1):151. doi: 10.1038/s41398-023-02397-3. Transl Psychiatry. 2023. PMID: 37147277 Free PMC article.
• Porcine Small Intestinal Submucosa Alters the Biochemical Properties of Wound Healing: A Narrative Review.
  Fujii M, Tanaka R. Fujii M, et al. Biomedicines. 2022 Sep 7;10(9):2213. doi: 10.3390/biomedicines10092213. Biomedicines. 2022. PMID: 36140314 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations