Key components of the fission machinery are interchangeable - PubMed (original) (raw)

. 2006 Dec;8(12):1376-82.

doi: 10.1038/ncb1503. Epub 2006 Nov 5.

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• PMID: 17086176
• DOI: 10.1038/ncb1503

Key components of the fission machinery are interchangeable

Jia-Shu Yang et al. Nat Cell Biol. 2006 Dec.

Abstract

Brefeldin-A ADP-ribosylated substrate (BARS) and dynamin function in membrane fission in distinct intracellular transport pathways, but whether their functions are mechanistically similar is unclear. Here, we show that ARFGAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor 1 (ARF1), couples to either BARS or endophilin B for vesicle formation by the coat protein I (COPI) complex - a finding that reveals an unanticipated mechanistic flexibility in mammalian COPI transport. Because dynamin is coupled to endophilin A in vesicle formation by the clathrin-coat complex, our finding also predicts that dynamin and ARF GAPs are likely to be functional counterparts in membrane fission among different transport pathways that connect intracellular membrane compartments.

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