Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage - PubMed (original) (raw)
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- PMID: 17089047
Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage
Stefania Gelmini et al. Oncol Rep. 2006 Dec.
Abstract
We tested Tankyrase-1 mRNA expression in colon cancer patients to evaluate the prognostic role of this parameter by real-time RT-PCR in a retrospective group of 82 unselected patients with colon cancer. Paired cancer and corresponding not affected tissues were used. Laser-assisted microdissection was used to measure Tankyrase-1 mRNA in homogeneous cancer cell populations and in normal colon epithelium of the same patients. Tankyrase-1 mRNA in colon cancers, as a mean, was significantly higher than in paired not affected tissues (p<0.0001), but its level correlates inversely with a cancer progression stage. Survival analysis indicated that lower Tankyrase-1 mRNA expression in colon cancers was significantly associated to reduced patient survival (p=0.019) and disease-free interval (p=0.035), confirmed also in a multi-variate analysis.
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