Antibody persistence and immune memory elicited by combined hepatitis A and B vaccination in older adults - PubMed (original) (raw)
Clinical Trial
. 2007 Feb 9;25(8):1503-8.
doi: 10.1016/j.vaccine.2006.10.024. Epub 2006 Oct 27.
Affiliations
- PMID: 17097774
- DOI: 10.1016/j.vaccine.2006.10.024
Clinical Trial
Antibody persistence and immune memory elicited by combined hepatitis A and B vaccination in older adults
Thomas Höhler et al. Vaccine. 2007.
Abstract
Response to hepatitis A and B vaccines has been reported to decline with age. This open, prospective, single-site study examined the long-term response to the combined hepatitis A/B vaccine Twinrix in 98 primary responders aged 45-67 years. Levels of antibody against hepatitis A virus (HAV) and hepatitis B surface antigen (HBs) were tested 30 months after initial vaccination. At this stage, all participants remained seropositive for anti-HAV and 70% for anti-HBs. A booster vaccination was offered to those who had responded to the first vaccination but then lost protective levels of anti-HBs. An anamnestic response was observed in all cases.
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