Synthesis and screening of N-alkyl hydroxamates for inhibition of cancer cell proliferation - PubMed (original) (raw)

Synthesis and screening of N-alkyl hydroxamates for inhibition of cancer cell proliferation

Keith J Stanger et al. Comb Chem High Throughput Screen. 2006 Nov.

Abstract

A small library of N-alkylated amino acid-derived sulfonamide hydroxamates was synthesized on solid phase and tested for inhibition of proliferation of the highly invasive breast cancer cell line MDA-MB-231. The most active compound 4317 inhibited cell growth at IC(50) 30 microM. N-alkylation of N-H hydroxamate-based MMP inhibitors, a modification known to eliminate MMP activity, enhanced cell proliferation inhibition potency.

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