The mitotic spindle matrix: a fibro-membranous lamin connection - PubMed (original) (raw)
Review
doi: 10.4161/cc.5.20.3365. Epub 2006 Oct 16.
Affiliations
- PMID: 17102624
- DOI: 10.4161/cc.5.20.3365
Review
The mitotic spindle matrix: a fibro-membranous lamin connection
Yixian Zheng et al. Cell Cycle. 2006 Oct.
Abstract
The mitotic spindle apparatus has attracted the attention of cell biologists for decades. Whereas the main function of this microtubule-based system is to segregate chromosomes, spindle morphogenesis and chromosome segregation must also coordinate with the segregation of the whole cell. The finding that RanGTPase stimulates the assembly of a lamin B-containing membranous matrix in mitosis(1) may provide a connection between the segregation of mitotic chromosomes and the partitioning of membrane systems during cell division.