The mechanistic classification of addictive drugs - PubMed (original) (raw)
Review
The mechanistic classification of addictive drugs
Christian Lüscher et al. PLoS Med. 2006 Nov.
Abstract
The authors review recent research on the molecular mechanisms of addiction and propose a new classification for addictive drugs.
Conflict of interest statement
Competing Interests: The authors have declared that no competing interests exist.
Figures
Figure 1. The Dominant Targets Involved in Increasing Dopamine for the Major Types of Addictive Drugs
G, Gi/o-coupled receptors; i, ionotropic receptors/ion channels; T, monoamine transporters
References
- Nestler EJ. Is there a common molecular pathway for addiction? Nat Neurosci. 2005;8:1445–1449. - PubMed
- Pierce RC, Kumaresan V. The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev. 2006;30:215–238. - PubMed
- Berridge KC, Robinson TE. What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev. 1998;28:309–369. - PubMed
- Bechara A, Nader K, van der Kooy D. A two-separate-motivational-systems hypothesis of opioid addiction. Pharmacol Biochem Behav. 1998;59:1–17. - PubMed
- Laviolette SR, van der Kooy D. Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area. Mol Psychiatry. 2003;8:50–59. - PubMed
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