Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins - PubMed (original) (raw)
. 2006 Oct;102(4):369-71.
doi: 10.1263/jbb.102.369.
Affiliations
- PMID: 17116587
- DOI: 10.1263/jbb.102.369
Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins
Hiroki Hamada et al. J Biosci Bioeng. 2006 Oct.
Abstract
We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl beta-cyclodextrin was the most effective and its solubility was 2.3 mM in a 0.1 M 2,6-dimethyl beta-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl beta-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.
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