Novel thiophene-, pyrrole-, furan-, and benzenecarboxamidotetrazoles as potential antiallergy agents - PubMed (original) (raw)
. 1991 Jul;34(7):2186-94.
doi: 10.1021/jm00111a039.
Affiliations
- PMID: 1712394
- DOI: 10.1021/jm00111a039
Novel thiophene-, pyrrole-, furan-, and benzenecarboxamidotetrazoles as potential antiallergy agents
M D Mullican et al. J Med Chem. 1991 Jul.
Abstract
The synthesis and antiallergic activity of a series of novel thiophene-, pyrrole-, furan-, and benzenecarboxamidotetrazoles are described. A number of compounds inhibit the release of histamine from anti-IgE-stimulated human basophils. Optimal inhibition is exhibited in compounds with a 3-alkoxy, a 4-halo, and a 5-methyl, 5-methoxy, or 5-bromo on a thiophene-2-carboxamidotetrazole.
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