The Barr body is a looped X chromosome formed by telomere association - PubMed (original) (raw)

The Barr body is a looped X chromosome formed by telomere association

C L Walker et al. Proc Natl Acad Sci U S A. 1991.

Abstract

We examined Barr bodies formed by isodicentric human X chromosomes in cultured human cells and in mouse-human hybrids using confocal microscopy and DNA probes for centromere and subtelomere regions. At interphase, the two ends of these chromosomes are only a micron apart, indicating that these inactive X chromosomes are in a nonlinear configuration. Additional studies of normal X chromosomes reveal the same telomere association for the inactive X but not for the active X chromosome. This nonlinear configuration is maintained during mitosis and in a murine environment.

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References

    1. Am J Hum Genet. 1987 Sep;41(3):374-90 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 May;83(9):2934-8 - PubMed
    1. Hum Genet. 1985;71(4):288-93 - PubMed
    1. Hum Genet. 1985;69(2):122-9 - PubMed
    1. Science. 1990 Aug 24;249(4971):928-32 - PubMed

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