The role of actomyosin and the microtubular network in both the immunological synapse and T cell activation - PubMed (original) (raw)
Review
doi: 10.2741/2073.
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- PMID: 17127308
- DOI: 10.2741/2073
Review
The role of actomyosin and the microtubular network in both the immunological synapse and T cell activation
Mercedes Rey et al. Front Biosci. 2007.
Abstract
The formation of immunological synapses between T cells and APCs, as well as the functions associated with this structure, like cytokine secretion and the lysis of infected cells, are critical processes in the immune response. The T cell cytoskeleton is involved in these activities and this has been the subject of numerous studies in recent years. Although the importance of the T cell actin network is evident, the participation of microtubules and myosin motors in the formation of immunological synapses and T cell effector functions has also been assessed. This review provides an update on the role of cytoskeletal networks and related molecules in the activation of T lymphocytes.
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