Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation - PubMed (original) (raw)

. 2007 Feb 9;282(6):4045-56.

doi: 10.1074/jbc.M608653200. Epub 2006 Dec 1.

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• PMID: 17142811
• DOI: 10.1074/jbc.M608653200

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Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation

Takeshi Nagashima et al. J Biol Chem. 2007.

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Erratum in

• J Biol Chem. 2014 Jul 25;289(30):20491

Abstract

ErbB receptor ligands, epidermal growth factor (EGF) and heregulin (HRG), induce dose-dependent transient and sustained intracellular signaling, proliferation, and differentiation of MCF-7 breast cancer cells, respectively. In an effort to delineate the ligand-specific cell determination mechanism, we investigated time course gene expressions induced by EGF and HRG that induce distinct cellular phenotypes in MCF-7 cells. To analyze independently the effects of ligand dosage and time for gene expression, we developed a statistical method for estimating the two effects. Our results indicated that signal transduction pathways convey quantitative properties of the dose-dependent activation of ErbB receptor to early transcription. The results also implied that moderate changes in the expression levels of a number of genes, not the predominant regulation of a few specific genes, might cooperatively work at the early stage of the transcription for determining cell fate. However, the EGF- and HRG-induced distinct signal durations resulted in the ligand-oriented biphasic induction of proteins after 20 min. The selected gene list and HRG-induced prolonged signaling suggested that transcriptional feedback to the intracellular signaling results in a graded to biphasic response in the cell determination process and that each ErbB receptor is inextricably responsible for the control of amplitude and duration of cellular biochemical reactions.

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