An evolutionary view of human recombination - PubMed (original) (raw)
Review
doi: 10.1038/nrg1947. Epub 2006 Dec 5.
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- PMID: 17146469
- DOI: 10.1038/nrg1947
Review
An evolutionary view of human recombination
Graham Coop et al. Nat Rev Genet. 2007 Jan.
Abstract
Recombination has essential functions in mammalian meiosis, which impose several constraints on the recombination process. However, recent studies have shown that, in spite of these roles, recombination rates vary tremendously among humans, and show marked differences between humans and closely related species. These findings provide important insights into the determinants of recombination rates and raise new questions about the selective pressures that affect recombination over different genomic scales, with implications for human genetics and evolutionary biology.
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